Results 51 to 60 of about 161,258 (216)

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Strong, Weak and Merging Lines in Atomic Spectra

Plasma
We present analytical estimates for the maximum line strength in a transition array, as well as for the numbers of strong and weak lines. For that purpose, two main assumptions are used as concerns the line strength distribution.
Jean-Christophe Pain
doaj   +1 more source

ASAS: Computational code for Analysis and Simulation of Atomic Spectra

SoftwareX, 2017
The laser isotopic separation process is based on the selective photoionization principle and, because of this, it is necessary to know the absorption spectrum of the desired atom.
Jhonatha R. dos Santos, Luiz F.N. Barreta, Maria E. Sbampato, Marcelo G. Destro   +3 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Line Ratio in the C-like Ion Spectrum O III: Testing Atomic Theory Predictions Through the Observation of Galaxies

Astronomy
The progress made in atomic structure computations has indicated that certain line ratios of forbidden transitions may be slightly different from earlier assumptions.
Julius Richard Dreisbach, Dominik J. Bomans, Elmar Träbert   +2 more
doaj   +1 more source

R-Matrix Scattering Calculations for Iron-Peak Species: Photoionisation of Fe I and Electron-Impact Excitation of Fe II

Galaxies, 2018
An abundance of absorption and emission lines of iron-peak species such as Fe I and Fe II can be seen in the spectra of many astrophysical objects. Thus, the accurate modelling of such spectra requires sets of high quality atomic data for these species ...
Ryan T. Smyth, Catherine A. Ramsbottom, Connor P. Ballance   +2 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Energy Levels and Transition Data of Cs VI

Atoms
Previously reported atomic data (spectral lines, wavelengths, energy levels, and transition probabilities) were collected and systematically analyzed for Cs VI.
Abid Husain, Haris Kunari, Tauheed Ahmad
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source