Results 71 to 80 of about 366,004 (264)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Improvement of mechanical properties and investigation of strengthening mechanisms on the Ti3AlC2 ceramic with nanosized WC addition

Journal of Advanced Ceramics
Ti3AlC2 (TAC) has great potential for use as an ablation material in aerospace applications due to its great oxidation/ablation resistance, but its high-temperature strength and thermal shock resistance still have much room for simultaneous improvement ...
Yi Zhong, Ying Liu, Qinkai Jiang, Na Jin, Zifeng Lin, Jinwen Ye   +5 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Simulated Photoabsorption Spectra for Singly and Multiply Charged Ions

Atoms
Simulated (or measured) photoabsorption spectra often provide the first indication of how matter interacts with light when irradiated by some radiation source. In addition to the direct, often slowly varying photoabsorption cross-section as a function of
Stephan Fritzsche, Aloka Kumar Sahoo, Lalita Sharma, Stefan Schippers   +3 more
doaj   +1 more source

Direct structure analysis of advanced nanomaterials by high-resolution electron microscopy

Nanotechnology Reviews, 2012
High-resolution electron microscopy (HREM) analysis has contributed to the direct structure analysis of advanced nanostructured materials, of which the properties of these materials are strongly dependent on the atomic arrangements.
Oku Takeo
doaj   +1 more source

Radiative Decay Rates for Electric Dipole, Magnetic Dipole and Electric Quadrupole Transitions in Triply Ionized Thulium (Tm IV)

Atoms, 2017
A new set of radiative decay parameters (oscillator strengths, transition probabilities) for spectral lines in triply ionized thulium (Tm IV) has been obtained within the framework of the pseudo-relativistic Hartree-Fock (HFR) approach.
Saturnin Enzonga Yoca, Pascal Quinet
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Detailed Analysis of Configuration Interaction and Calculation of Radiative Transition Rates in Seven Times Ionized Tungsten (W VIII)

Atoms, 2015
A new set of oscillator strengths and transition probabilities for EUV spectral lines of seven times ionized tungsten (W VIII) is reported in the present paper.
Jérôme Deprince, Pascal Quinet
doaj   +1 more source