Results 131 to 140 of about 66,220 (306)

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

Old and new forms of communication between the state and society on the way to a new social contract

RUDN journal of Sociology
The article considers the concept of social contract as a consensus between the state and the people. Based on the works of T. Hobbes, D. Locke, J.-J. Rousseau, C. Montesquieu, German social thought, in the context of reflections on the “legitimacy” of R.
R. I. Anisimov
doaj   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Influence of Process Parameters on the Ultrasonic Atomization Efficiency and Possibility of Testing Properties of Liquid Metals

Metrology
Over recent years, ultrasonic atomization, especially with regard to liquid metals, has become an object of increased interest, mainly from industry, for additive manufacturing, but also from investigators, for research purposes.
Rafał Szostak-Staropiętka, Wojciech Presz, Roksana Pawlic, Anna Dziubińska, Katarzyna Kołacz   +4 more
doaj   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

Interpreting Image Patterns for Agricultural Sprays Using Statistics and Machine Learning Techniques

Fluids
The atomization of liquid spray solutions through nozzles is a mechanism for delivering many pesticides to the target. The smallest drop sizes (
Steven Cryer, John Raymond
doaj   +1 more source

Discrete element modeling and fibre optical measurements for fluidized bed spray granulation [PDF]

, 2006
Spout fluidized beds are frequently used for the production of granules or\ud particles through granulation. The products find application in a large variety of\ud applications, for example detergents, fertilizers, pharmaceuticals and food.
Deen, N.G., Godlieb, W., Heinrich, S., Kuipers, J.A.M., Link, J.M., Mörl, L., Peglow, M., Schönherr, M., Tripp, P.   +8 more
core   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source