Results 251 to 260 of about 224,178 (338)

Profiling a Neo‐Antigen‐Driven Immune Response in Healthy Volunteers: A Randomized, Double‐Blind, Placebo‐Controlled Study of the KLH Challenge Model

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Novel compounds targeting the adaptive immune system are commonly initially investigated in healthy volunteers (HV). HV frequently lack constitutively expressed drug‐target engagement biomarkers, complicating the evaluation of pharmacological activity. The keyhole limpet hemocyanin (KLH) neo‐antigen challenge elicits a controlled immune response in HV ...
Micha N. Ronner   +10 more
wiley   +1 more source

Fifty years of research on the Joulters ooid sandbody—Impact on carbonate sedimentology and diagenesis and lessons learned from an invaluable analogue

open access: yesThe Depositional Record, EarlyView.
The Joulters ooid sandbody of northern Great Bahama Bank is a vast expanse of muddy ooid sands partly rimmed by clean ooid sands and formed into a relatively thick layer of significant extent. Knowledge of the development of depositional and diagenetic patterns in the Joulters example has forwarded our general understanding of carbonate sedimentology ...
Harris Paul
wiley   +1 more source

Redefining the Skin Barrier: A Microbiome‐Integrated Multilayered Defense Model

open access: yesBarrier Immunity, EarlyView.
ABSTRACT The skin constitutes a dynamic interface orchestrating a sophisticated multilayered defense system comprising physical, chemical, immune, and microbial barriers. This review synthesizes current understanding of the structural and functional integration of these barriers, emphasizing their synergistic interactions in maintaining cutaneous ...
Jingjing Xia   +4 more
wiley   +1 more source

Comparative Studies of Keratins Isolated from Psoriasis and Atopic Dermatitis

open access: bronze, 1980
Millard P. Thaler   +3 more
openalex   +1 more source

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