Results 121 to 130 of about 79,824 (366)

Role for Complement C5 in Eosinophilic Inflammation of Severe Asthma

Allergy, EarlyView.
Complement activation module, particularly C5, is positively associated with eosinophilic inflammation in severe asthma cohorts. Elevated C5 expression correlates with poor lung function improvement and persistent eosinophilic inflammation. Mouse model studies confirm that C5 exacerbates eosinophilic inflammation, highlighting its potential as a ...
Cong Dong, Shaohua Lu, Zhenan Deng, Xuliang Cai, Huahao Shen, Guochao Shi, Changxing Ou, Zuofu Peng, Wei Jiang, Xiuhua Fu, Changzheng Wang, Meiling Jin, Zhongmin Qiu, Xiaoyang Wei, Wei Gu, Kewu Huang, Qiang Li, Xiangyan Zhang, Nanshan Zhong, Kian Fan Chung, Qingling Zhang, on behalf of C‐BIOPRED Consortium, Jiangtao Lin, Yongming Zhang, Nan Su, Xiaoyan Zhang, Qing Zhao, Ying Nong, Ping Chen, Tianyi Zhu, Binbin Ji, Yan Wang, Haitao Zhao, Jinbao Wang, Zhiyuan Zhang, Xiaona Yang, Chunhua Wei, Jing Han, Nong Yu, Qiang Li, Zhifu Yang, Yanhong Liu, Guohua Li, Huadong Guan, Shuping Zhang, Xiuhua Fu, Lihong Wang, Lingxin Meng, Zhenting Sun, Guangqin Cao, Lei Zhao, Kewu Huang, Hong Zhang, Wen Wang, Li An, Yangyu Chen, Yanli Gao, Xiaoxia Liu, Huifen Zhai, Fang Lin, Zhaohui Zhong, Zhongguang Wen, Yan Xiao, Jian Kang, Linfei Kong, Xinming Su, Xue Yan, Dijia Zhou, Huaping Tang, Wei Han, Yi Shu, Tintian Li, Lixin Xie, Hong Hu, Bo Liu, Yuzhu Li, Longmei Fan, Yue Zhang, Shifeng Zhao, Xiaofang Liu, Yuhong Wang, Xichun Zhang, Xinmao Wang, Pen Bai, Guangfa Wang, Yan Hu, Zhanwei Hu, Ju Cao, Bei He, Rui Wu, Xiaoyan Gai, Hong Zhu, Zhihai Han, Jiyi Meng, Wei Chen, Li Ma, Zhenqian Liu, Chunyang Zhang, Yan Zhang, Huahao Shen, Fugui Yan, Bin Shen, Xinghong Wang, Hao Zhang, Yinghua Yin, Jinkai Liu, Yanxiong Mao, Mao Huang, Xin Yao, Mao Huang, Ji Zhou, Zhenzhen Wu, Ping Yan, Yujie Zhang, Xinling Yang, Ningfei Ji, Fan Fei, Wanzhen Fu, Yi Yang, Yuting Shi, Wangjian Cha, Guochao Shi, Min Zhou, Wei Tang, Wei Chen, Jun Zhou, Wenjie Yang, Lei Zhu, Meiling Jin, Liping Xue, Li Li, Chun Li, Yin Gong, Qiang Li, Guogang Xie, Luhong Bao, Wuping Bao, Nianyun Li, Fengming Ding, Min Zhang, Zhongmin Qiu, Li Yu, Jungang Xie, Lingling Yi, Xianghuai Xu, Qiang Chen, Junjun Tang, Jinfu Xu, Xiaobing Ji, Jingyun Shi, Bo Su, Xiaojun Yang, Jiuwen Bai, Shuo Liang, Kebing Cheng, Wei Gu, Jiyong Ma, Yun Liu, Jun Ren, Shan Mao, Qingling Zhang, Baoqing Sun, Jiaxing Xie, Rihuang Qiu, Zhiqiang Wang, Peiyan Zhen, Wenting Luo, Changgao Zhong, Wei Luo, Yanqing Xie, Xinxin Yu, Wenting Yu, Wei He, Changzheng Wang, Qianli Ma, Min Wan, Mingzhou Zhang, Haining Li, Shaoxi Cai, Haijin Zhao, Yanmei Ye, Fang Zhou, Laiyu Liu, Guohua Huang, Jianpeng Liang, Jianping Zhao, Jungang Xie, Qiongjie Hu, Kaiyan Li, Wang Ni, Guohua Zheng, Weining Xiong, Lingling Yi, Xihu Du, Yunhui Zhang, Zhi Li, Xiaoqiong Tan, Feng Liao, Shenglan Wang, Yijiang Huang, Xinjun Cai, Kai Liu, Shaojing Sheng, Yihui Fu, Shenghua Sun, Qiang Zhang, Jinweng Cai, Ye Ling, Pin Chen, Hong Luo, Lv Liu, Zhijun Liu, Yuling Tang, Yusheng Yan, Guiyan Mo, Long Wen, Yinqun Zhu, Du Fan   +217 more
wiley   +1 more source

Allosteric inhibition of IgE–FcεRI interactions by simultaneous targeting of IgE F(ab’)2 epitopes

Communications Biology
Immunoglobulin E (IgE) plays pivotal roles in allergic diseases through interaction with a high-affinity receptor (FcεRI). We established that Fab fragments of anti-IgE antibodies (HMK-12 Fab) rapidly dissociate preformed IgE-FcεRI complexes in a ...
Takao Hirano, Akemi Koyanagi, Hideo Ago, Masaki Yamamoto, Jiro Kitaura, Masataka Kasai, Ko Okumura   +6 more
doaj   +1 more source

Bronchial responsiveness is related to increased exhaled NO (FE(NO)) in non-smokers and decreased FE(NO) in smokers.

PLoS ONE, 2012
RationaleBoth atopy and smoking are known to be associated with increased bronchial responsiveness. Fraction of nitric oxide (NO) in the exhaled air (FE(NO)), a marker of airways inflammation, is decreased by smoking and increased by atopy. NO has also a
Andrei Malinovschi, Christer Janson, Marieann Högman, Giovanni Rolla, Kjell Torén, Dan Norbäck, Anna-Carin Olin   +6 more
doaj   +1 more source

Maternal Geohelminth Infections Are Associated with an Increased Susceptibility to Geohelminth Infection in Children: A Case-Control Study [PDF]

, 2012
Background: Children of mothers infected with soil-transmitted helminths (STH) may have an increased susceptibility to STH infection. Methods and Findings: We did a case-control study nested in a birth cohort in Ecuador.
Alejandro Rodriguez, Carlos Sandoval, Charles H. King, Edward Mitre, Fernanda Tupiza, Irene Guadalupe, Martha Chico, Nely Broncano, Philip J. Cooper, Raaj S. Mehta   +9 more
core   +2 more sources

Atopy and work.

Scandinavian Journal of Work, Environment & Health, 1984
Atopy denotes the exceptional capacity to produce immunoglobulin (Ig)E antibody when exposed to common environmental allergens. The characteristic is frequently used for preemployment screening purposes. Too little attention has, however, been paid to the rationale and the consequences of this practice.
openaire   +4 more sources

3D Model of Human Epidermis Exposed to Staphylococci Reveals Keratinocyte Responses Unique to Atopy‐Associated S. aureus Challenge

Allergy, EarlyView.
Piotr Brzoza, Michelle Camacho, Mariia Tyshchenko, Agnieszka Morytko, Mateusz Kwitniewski, Maciej Pastuszczak, Paulina Stepinska, Marcin Migaczewski, Joanna Cichy   +8 more
wiley   +1 more source

High‐Dimensional Analysis of Type 2 Lymphocyte Dynamics During Mepolizumab or Dupilumab Treatment in Severe Asthma

Allergy, EarlyView.
We profiled PBMCs in severe asthma patients at baseline and after initiating treatment with mepolizumab or dupilumab. Mepolizumab treatment increases ILC2, Th2, and Tc2 cell frequencies, skewing ILC2 towards CD117low and Th2/Tc2 cells towards a central memory phenotype.
Lorenz Wirth, Whitney Weigel, Christopher T. Stamper, Johan Kolmert, Sabrina de Souza Ferreira, Quirin Hammer, Maria Sparreman Mikus, Jakob Theorell, Lars Andersson I, Ann‐Sofie Lantz, Eva Wallén‐Nielsen, Anne Petrén, Craig E. Wheelock, Apostolos Bossios, Nikolaos Lazarinis, Andrei Malinovschi, Christer Janson, Barbro Dahlén, Thomas Hochdörfer, Christopher Andrew Tibbitt, Sven‐Erik Dahlén, Valentyna Yasinska, Jenny Mjösberg   +22 more
wiley   +1 more source

Effects of atopy and rhinitis on exhaled nitric oxide values - a systematic review

Clinical and Translational Allergy, 2011
Background Atopy and rhinitis are among the factors affecting exhaled nitric oxide (FeNO) values and may contribute to difficulties in the clinical interpretation of FeNO measurements.
Linhares Daniela, Jacinto Tiago, Pereira Ana M, Fonseca João A   +3 more
doaj   +1 more source

Tailored interventions based on exhaled nitric oxide versus clinical symptoms for asthma in children and adults [PDF]

, 2009
BackgroundThe measurement of severity and control of asthma in both children and adults can be based on subjective or objective measures. It has been advocated that fractional exhaled nitric oxide (FeNO) can be used to monitor airway inflammation as it ...
American Thoracic Society, Douwes, Dupont, Franklin, Franklin, Fritsch, Gelb, Griese, Higgins, Jatakanon, Jatakanon, Jones, Jones, Jongste, Kharitonov, Kharitonov, Lim, Malmberg, Malmberg, Nordvall, Petsky, Pijnenburg, Pijnenburg, Prasad, Sanders, Shaw, Smith, Strunk, Szefler, Szefler, Zacharasiewicz   +30 more
core   +4 more sources

Atopic Status Is Associated With Kidney Transplanted Recipients' Outcomes

Allergy, EarlyView.
Luc Colas, Marine Lorent, Fanny Feuillet, Clarisse Kerleau, Emmanuelle Papuchon, Caroline Hemont, Cécile Braudeau, Florent Delbos, Karine M. Renaudin, Magali Giral, Sophie Brouard, DIVAT Consortium, Gilles Blancho, Julien Branchereau, Diego Cantarovich, Anne Cesbron, Agnès Chapelet, Jacques Dantal, Clément Deltombe, Anne Devis, Lucile Figueres, Claire Garandeau, Caroline Gourraud‐Vercel, Christine Kandell, Aurélie Meurette, Anne Moreau, Simon Ville, Alexandre Walencik   +27 more
wiley   +1 more source