Results 351 to 360 of about 127,756 (395)

ATP‐binding cassette transporters and cholesterol translocation

IUBMB Life, 2013
AbstractCholesterol, a major component of mammalian cell membranes, plays important structural and functional roles. However, accumulation of excessive cholesterol is toxic to cells. Aberrant cholesterol trafficking and accumulation is the molecular basis for many diseases, such as atherosclerotic cardiovascular disease and Tangier's disease ...
Ge, Li, Hong-Mei, Gu, Da-Wei, Zhang
openaire   +3 more sources

Evolution of ATP-binding cassette transporter genes

Current Opinion in Genetics & Development, 1995
The transport of molecules across lipid membranes is an essential function of all living organisms. One of the families of genes that have evolved to carry out this function is that which encodes the ATP-binding cassette proteins. These molecules use active transport to pump specific molecules across membranes, and the genes that encode them are found ...
M, Dean, R, Allikmets
openaire   +2 more sources

Yeast ATP-Binding Cassette Transporters Conferring Multidrug Resistance

Annual Review of Microbiology, 2012
Overexpression of the ATP-binding cassette (ABC) drug transporter P-glycoprotein (P-gp) is often responsible for the failure of chemotherapy as a treatment for human tumors. The presence of proteins homologous to P-gp in organisms ranging from prokaryotes to eukaryotes indicates that drug export is a general mechanism of multidrug resistance.
Rajendra, Prasad, Andre, Goffeau
openaire   +2 more sources

Hepatocellular Transport: Role of ATP-Binding Cassette Proteins

Seminars in Liver Disease, 1996
The interest of mammalian biologists in ATP-binding cassette (ABC) proteins is relatively recent. However, ABC proteins are widespread in distribution and have long been known to play an important transport role in prokaryotes. The review includes a brief overview of the structure, regulation, and varied functions of ABC proteins in different cell ...
N, Lomri, J G, Fitz, B F, Scharschmidt
openaire   +2 more sources

The Genetics of ATP‐Binding Cassette Transporters

2005
The ATP-binding cassette (ABC) superfamily consists of membrane proteins that transport a wide variety of substrates across membranes. Mutations in ABC transporters cause or contribute to a number of different Mendelian disorders, including adrenoleukodystrophy, cystic fibrosis, retinal degeneration, cholesterol, and bile transport defects. In addition,
openaire   +2 more sources

The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease

Nature Genetics, 1999
M. Bodzioch, E. Orso, J. Klucken, T. Langmann, A. Böttcher, Wendy Diederich, W. Drobnik, S. Barlage, C. Büchler, M. Porsch-Özçürümez, W. Kaminski, H. Hahmann, K. Oette, G. Rothe, C. Aslanidis, K. Lackner, G. Schmitz   +16 more
semanticscholar   +1 more source

Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1

Nature Genetics, 1999
S. Rust, Marie Rosier, H. Funke, J. Real, Z. Amoura, J. Piette, J. Deleuze, H. Brewer, N. Duverger, P. Denéfle, G. Assmann   +10 more
semanticscholar   +1 more source

ATP-binding cassette transporter A1 and cholesterol trafficking

Current Opinion in Lipidology, 2002
Two hallmarks of cardiovascular disease are the presence of sterol-laden macrophages in the artery wall and reduced plasma HDL levels. A cell membrane protein named ATP-binding cassette transporter A1 (ABCA1) mediates secretion of excess cholesterol from cells into the HDL metabolic pathway.
openaire   +2 more sources

Structure and Function of Hepatobiliary ATP Binding Cassette Transporters

Chemical Reviews, 2021
Sander H J Smits, Lutz Schmitt
exaly  

A five-transgene cassette confers broad-spectrum resistance to a fungal rust pathogen in wheat

Nature Biotechnology, 2021
Aihua Wang, Oadi Matny, Mehran Patpour
exaly