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Impact of Drug–Drug Interactions on Clinical Outcomes in Metastatic Melanoma Patients Treated With Combined BRAF/MEK Inhibitors: A Real‐World Study

Pigment Cell &Melanoma Research, Volume 38, Issue 4, July 2025.
ABSTRACT The unique pharmacokinetics of BRAF and MEK inhibitors make patients vulnerable to drug–drug interactions (DDIs), which may compromise treatment efficacy in metastatic melanoma. This study evaluates the impact of DDIs on clinical outcomes in patients with metastatic melanoma treated with BRAF/MEK inhibitors.
Silvia Mezi, Andrea Botticelli, Giulia Pomati, Simone Scagnoli, Giulia Fiscon, Federica de Galitiis, Francesca Romana di Pietro, Sofia Verkhovskaia, Sasan Amirhassankhani, Giovanna Gentile, Maurizio Simmaco, Bjoern Gohlke, Robert Preissner, Daniele Santini, Paolo Marchetti   +14 more
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ATP-binding cassette transporters and neurodegenerative diseases

Essays in Biochemistry, 2021
Abstract ATP-binding cassette (ABC) transporters are one of the largest groups of transporter families in humans. ABC transporters mediate the translocation of a diverse range of substrates across cellular membranes, including amino acids, nucleosides, lipids, sugars and xenobiotics.
Jared S. Katzeff, Woojin Scott Kim
openaire   +2 more sources

ATP-Binding Cassette Transporters in the Heart

Trends in Cardiovascular Medicine, 2006
Members of the ATP-binding cassette (ABC) protein superfamily are integral membrane proteins involved in energy-dependent transport of a wide variety of substrates across biologic membranes. ATP-binding cassette transporters serve as functional barriers against the entry of xenobiotics, for example, in the intestine or at the blood-brain barrier, or ...
Thomas F. Solbach, Martin F. Fromm, Oliver Zolk, Jörg König   +3 more
openaire   +3 more sources

ATP-Binding Cassette Transporters in Bacteria

Annual Review of Biochemistry, 2004
▪ Abstract  ATP-binding cassette (ABC) transporters couple ATP hydrolysis to the uptake and efflux of solutes across the cell membrane in bacteria and eukaryotic cells. In bacteria, these transporters are important virulence factors because they play roles in nutrient uptake and in secretion of toxins and antimicrobial agents. In humans, many diseases,
Jue Chen, Amy L. Davidson
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ATP‐binding cassette transporters in liver

BioFactors, 2013
AbstractThe human ATP‐binding cassette (ABC) superfamily consists of 48 members with 14 of them identified in normal human liver at the protein level. Most of the ABC members act as ATP dependent efflux transport systems. In the liver, ABC transporters are involved in diverse physiological processes including export of cholesterol, bile salts, and ...
Katrin Wlcek, Bruno Stieger
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ATP‐binding cassette transporters and cholesterol translocation

IUBMB Life, 2013
AbstractCholesterol, a major component of mammalian cell membranes, plays important structural and functional roles. However, accumulation of excessive cholesterol is toxic to cells. Aberrant cholesterol trafficking and accumulation is the molecular basis for many diseases, such as atherosclerotic cardiovascular disease and Tangier's disease ...
Da-Wei Zhang, Ge Li, Hong-mei Gu
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The Role of ATP-Binding Cassette Transporters in Bacterial Phytopathogenesis

Phytopathology®, 2021
Bacteria use selective membrane transporting strategies to support cell survival in different environments. Of the membrane transport systems, ATP-binding cassette (ABC) transporters, which utilize the energy of ATP hydrolysis to deliver substrate across the cytoplasmic membrane, are the largest and most diverse superfamily.
Yuan Zeng, Amy O. Charkowski
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ATP-binding cassette (ABC) transporters in atherosclerosis

Current Atherosclerosis Reports, 2002
Macrophages play a central role in the initiation and progression of atherosclerotic lesions. In the nascent lesion, macrophages transform into foam cells through the excessive accumulation of cholesteryl esters. Dysfunctional lipid homeostasis in macrophages and foam cells ultimately results in the breakdown of membrane integrity and cell death ...
Gerd Schmitz, Wolfgang E. Kaminski
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Evolution of ATP-binding cassette transporter genes

Current Opinion in Genetics & Development, 1995
The transport of molecules across lipid membranes is an essential function of all living organisms. One of the families of genes that have evolved to carry out this function is that which encodes the ATP-binding cassette proteins. These molecules use active transport to pump specific molecules across membranes, and the genes that encode them are found ...
Rando Allikmets, Michael Dean
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Plant ATP-Binding Cassette Transporters

Annual Review of Plant Biology, 2007
The ATP-binding cassette (ABC) protein superfamily is one of the largest known, with over 120 members in both Arabidopsis thaliana and rice (Oryza sativa). Most, but not all, ABC proteins are modularly organized membrane proteins (“ABC transporters”) that mediate MgATP-energized transmembrane transport and/or regulate other transporters.
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