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ATP-Binding Cassette Transporters: Snap-on Complexes?
2022ATP-binding cassette (ABC) transporters are one of the largest families of membrane proteins in prokaryotic organisms. Much is now understood about the structure of these transporters and many reviews have been written on that subject. In contrast, less has been written on the assembly of ABC transporter complexes and this will be a major focus of this
Iqra, Younus +4 more
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ATP-Binding Cassette Transporters and Their Roles in Protecting the Brain
The Neuroscientist, 2011The blood-brain barrier is a network of endothelial cells that are tightly attached with each other via specialized cell-cell contacts. This passive diffusion barrier is complemented by ATP-binding cassette (ABC) transporters, which are localized on the surface of the endothelial cells. ABC transporters play important roles in the maintenance of blood-
Elali, Ayman, Hermann, Dirk M.
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The Genetics of ATP‐Binding Cassette Transporters
2005The ATP-binding cassette (ABC) superfamily consists of membrane proteins that transport a wide variety of substrates across membranes. Mutations in ABC transporters cause or contribute to a number of different Mendelian disorders, including adrenoleukodystrophy, cystic fibrosis, retinal degeneration, cholesterol, and bile transport defects. In addition,
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ATP-binding cassette efflux transporters and MDR in cancer
Drug Discovery Today, 2023Of the many multidrug resistance (MDR) mechanisms, the ATP binding cassette (ABC) transporters expelling drug molecules out of cells is a major culprit in limiting the efficacy of present-day anticancer drugs. The present review offers an updated information on structure, function, and regulatory mechanisms of major MDR related ABC transporters such as
Manasi S, Pote, Rajesh N, Gacche
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Implications of ATP-binding cassette transporters for brain pharmacotherapies
Trends in Pharmacological Sciences, 2007By preventing pharmacological compounds from achieving therapeutic levels in tissue, ATP-binding cassette (ABC) transporters complicate new drug discoveries. This has profound implications for pharmacotherapies, which go far beyond the need to deliver higher drug dosages.
Claudio L. Bassetti, Dirk M. Hermann
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Hepatocellular Transport: Role of ATP-Binding Cassette Proteins
Seminars in Liver Disease, 1996The interest of mammalian biologists in ATP-binding cassette (ABC) proteins is relatively recent. However, ABC proteins are widespread in distribution and have long been known to play an important transport role in prokaryotes. The review includes a brief overview of the structure, regulation, and varied functions of ABC proteins in different cell ...
J. G. Fitz +2 more
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The role of ATP-binding cassette transporters in bacterial pathogenicity
Protoplasma, 2012The ATP-binding cassette transporter superfamily is present in all three domains of life. This ubiquitous class of integral membrane proteins have diverse biological functions, but their fundamental role involves the unidirectional translocation of compounds across cellular membranes in an ATP coupled process.
Pederick, V., Ween, M., McDevitt, C.
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Interrelationship between ATP-binding cassette transporters and oxysterols
Biochemical Pharmacology, 2013ATP-binding cassette (ABC) transporters constitute a ubiquitous superfamily of membrane proteins responsible for the translocation of several substances across membranes using the chemical energy provided by ATP hydrolysis. ABC transporters participate in many physiological and pathophysiological processes, including cholesterol and lipid ...
Debora Levy +3 more
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ATP-binding cassette transporter G1 and lipid homeostasis
Current Opinion in Lipidology, 2006This review briefly discusses the ATP-binding cassette transporter G (ABCG) family members and emphasizes recent studies that identify ABCG1 as a key regulator of cellular lipid homeostasis.The in-vivo importance of ABCG1 has recently been demonstrated with both loss-of-function and gain-of-function studies in mice.
Ángel Baldán +3 more
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ATP-Binding Cassette Transporters in Inflammatory Brain Disease
Current Pharmaceutical Design, 2011Owing to therapeutic progress, the role of ABC-transporters in infectious and autoimmune inflammatory CNS-diseases has recently gained considerable attention. In HIV-encephalitis and HIV-associated neurocognitive disorders, ABC-transporters are discussed to contribute to limited CNS-penetration and -retention of antiviral agents.
R. Gold, Andrew T. Chan, N. von Ahsen
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