Results 71 to 80 of about 12,282 (232)

Mammalian gene expression variability is explained by underlying cell state. [PDF]

, 2020
Gene expression variability in mammalian systems plays an important role in physiological and pathophysiological conditions. This variability can come from differential regulation related to cell state (extrinsic) and allele-specific transcriptional ...
Foreman, Robert, Wollman, Roy
core   +2 more sources

Molecular Changes Induced by Carbon Dioxide Laser in Hailey‐Hailey Disease: A Potential Mechanism Underlying Treatment Efficacy

International Journal of Dermatology, EarlyView.
ABSTRACT Introduction Hailey‐Hailey disease (HHD) is a rare genodermatosis caused by mutations in the ATP2C1 gene that codes for SPCA1, a calcium transporter in the epidermis. HHD impairs quality of life, and no curative treatment exists. Methods To confirm the efficacy and safety of CO2 laser in HHD, we conducted a randomized, prospective, controlled ...
Javier Antoñanzas, Agustín España, Ana Gorostidi, Ana Patiño‐García, Marcos J. Araúzo‐Bravo, Daniela Gerovska, Rafael Salido‐Vallejo, Leyre Aguado‐Gil   +7 more
wiley   +1 more source

Identification of two novel Darier disease-associated mutations in the ATP2A2 gene

Molecular Medicine Reports, 2015
Darier disease (DD) is an autosomal dominant inherited skin disorder, characterized by abnormal keratinization, loss of adhesion between epidermal cells, termed acantholysis, and the development of warty papules and plaques on the central trunk, forehead, scalp and flexures.
ZHENG, LIBAO, JIANG, HUILI, MEI, QIN, CHEN, BIN   +3 more
openaire   +3 more sources

Computational neuroanatomy and co-expression of genes in the adult mouse brain, analysis tools for the Allen Brain Atlas

, 2013
We review quantitative methods and software developed to analyze genome-scale, brain-wide spatially-mapped gene-expression data. We expose new methods based on the underlying high-dimensional geometry of voxel space and gene space, and on simulations of ...
Grange, Pascal, Hawrylycz, Michael, Mitra, Partha P.   +2 more
core   +1 more source

Transcriptomic Remodeling of Pulmonary Vein Sleeves Suggests a Role in Atrial Arrhythmogenesis in Thoroughbred Horses

Annals of the New York Academy of Sciences, EarlyView.
Myocardial sleeves of the pulmonary veins in racehorses with paroxysmal atrial fibrillation exhibit upregulated pathways associated with tissue structure remodeling. Pathways related to the extracellular matrix and cellular components differ significantly from those in healthy horses.
Magdalena Arevalo‐Turrubiarte, Charlotte E. Edling, Carla Moller‐Levet, Bronte Forbes, Victoria Kemp, Joe Weir, Celia Marr, Rebecca Lewis, Kamalan Jeevaratnam   +8 more
wiley   +1 more source

Large autosomal copy-number differences within unselected monozygotic twin pairs are rare [PDF]

, 2015
Monozygotic (MZ) twins form an important system for the study of biological plasticity in humans. While MZ twins are generally considered to be genetically identical, a number of studies have emerged that have demonstrated copy-number differences within ...
Martin, Nicholas G., Mcrae, Allan F., Montgomery, Grant W., Visscher, Peter M.   +3 more
core   +2 more sources

Data on dysfunctional muscle contraction and genes contractile expression associated with chlorpyrifos exposure in slow twitch skeletal muscle

Data in Brief, 2019
Chlorpyrifos (CPF) is a toxic organophosphate commonly used worldwide. Its residues are being detected in different environmental matrixes and hence in the food chain.
Nancy Hallal, Mahmoud Khalil, Mohamed E. Moustafa, Wiam Ramadan, Wissam H. Joumaa   +4 more
doaj   +1 more source

Anti-cancer perspectives of resveratrol: a comprehensive review

Food and Agricultural Immunology, 2023
Resveratrol (RVT) is well known for its chemo-preventive and therapeutic attributes against the various kinds of cancers such as breast, prostate, pancreatic, oral, brain, lung and liver.
Muhammad Junaid Anwar, Areeba Altaf, Muhammad Imran, Muhammad Amir, Suliman A. Alsagaby, Waleed Al Abdulmonem, Ahmed Mujtaba, Ahmed H. El-Ghorab, Mohammed M. Ghoneim, Muzzamal Hussain, Entessar Al Jbawi, Mohamed E. Shaker, Mohamed A. Abdelgawad   +12 more
doaj   +1 more source

Bacteriophage and Fusidic Acid Have Synergistic Effect Against Meticillin‐Resistant Staphylococcus pseudintermedius in Ex Vivo Canine Dermis Model

Veterinary Dermatology, EarlyView.
Background: Antimicrobial stewardship has become vital given the progressive emergence of multidrug‐resistant bacteria, and novel approaches to the treatment of bacterial infections are needed. Recently, reported synergistic effects of antibacterial drugs and bacteriophage therapy have revealed promising applications for the management of meticillin ...
Sarah Ehling, Elisa Peh, Hilke Oltmanns, Jessica Meissner, Sophie Kittler, Christina Puff, Jutta Verspohl, Mathias Müsken, Madeleine Plötz, Andrea Vanessa Volk   +9 more
wiley   +1 more source

ATP2A2 regulates STING1/MITA-driven signal transduction including selective autophagy

Autophagy
STING1/MITA not only induces innate immune responses but also triggers macroautophagy/autophagy to selectively degrade signaling molecules. However, the molecular mechanisms regulating STING1-mediated selective autophagy remain unclear. Here, we first report that ATP2A2 directly interacts with STING1, regulating STING1-mediated innate immune response ...
Yang, Xue, Lv, Linyue, Zhang, Yuelan, Zhang, Zhuyou, Zeng, Shaowei, Zhang, Xinyi, Wang, Qinyang, Dorf, Martin, Li, Shitao, Fu, Bishi   +9 more
openaire   +2 more sources