Results 91 to 100 of about 2,278 (176)

The Impact of a Non-Functional Thyroid Receptor Beta upon Triiodotironine-Induced Cardiac Hypertrophy in Mice

Cellular Physiology and Biochemistry, 2015
Background/Aims: Thyroid hormone (TH) signalling is critical for heart function. The heart expresses thyroid hormone receptors (THRs); THRα1 and THRβ1.
Güínever Eustáquio do Império, Isalira Peroba Ramos, Letícia Aragão Santiago, Guilherme Faria Pereira, Norma Aparecida dos Santos Almeida, Cesar Seigi Fuziwara, Carmen C. Pazos-Moura, Edna Teruko Kimura, Emerson Lopes Olivares, Tania Maria Ortiga-Carvalho   +9 more
doaj   +1 more source

Wireless optogenetics protects against obesity via stimulation of non-canonical fat thermogenesis. [PDF]

, 2020
Cold stimuli and the subsequent activation of β-adrenergic receptor (β-AR) potently stimulate adipose tissue thermogenesis and increase whole-body energy expenditure.
Ferro, Marc D, Ikeda, Kenji, Kajimura, Shingo, Oguri, Yasuo, Poon, Ada SY, Tajima, Kazuki, Tanabe, Yuji, Thomson, Ella A, Yoneshiro, Takeshi   +8 more
core  

A low-density SNP array for analyzing differential selection in freshwater and marine populations of threespine stickleback (Gasterosteus aculeatus) [PDF]

, 2014
BACKGROUND: The threespine stickleback (Gasterosteus aculeatus) has become an important model species for studying both contemporary and parallel evolution.
Bekkevold, Dorte, Ferchaud, Anne-Laure, Hansen, Michael Møller, Jian, Jianbo, Niu, Yongchao, Pedersen, Susanne H.   +5 more
core   +2 more sources

Endoplasmic reticulum stress-related deficits in calcium clearance promote neuronal dysfunction that is prevented by SERCA2 gene augmentation

Cell Reports Medicine
Summary: Disruption of calcium (Ca2+) homeostasis in neurons is a hallmark of neurodegenerative diseases. Here, we investigate the mechanisms leading to Ca2+ dysregulation and ask whether altered Ca2+ dynamics impinge on neuronal stress and circuit ...
Yukihiro Shiga, Aline Giselle Rangel Olguin, Sana El Hajji, Nicolas Belforte, Heberto Quintero, Florence Dotigny, Luis Alarcon-Martinez, Arjun Krishnaswamy, Adriana Di Polo   +8 more
doaj   +1 more source

Deficiency of MicroRNA miR‐1954 Promotes Cardiac Remodeling and Fibrosis

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Cardiac fibrosis occurs because of disruption of the extracellular matrix network leading to myocardial dysfunction. Angiotensin II (AngII) has been implicated in the development of cardiac fibrosis. Recently, microRNAs have been identified as
Valorie Chiasson, Ana Paula Cremasco Takano, Rakeshwar S. Guleria, Sudhiranjan Gupta   +3 more
doaj   +1 more source

Analysis of Contractile Function of Permeabilized Human Hypertrophic Cardiomyopathy Multicellular Heart Tissue

Frontiers in Physiology, 2019
Background: Many forms of hypertrophic cardiomyopathy (HCM) show an increased myofilament Ca2+ sensitivity. This observation has been mainly made in HCM mouse models, myofilament systems, and cardiomyocytes. Studies of multicellular tissues from patients
Nico Kresin, Nico Kresin, Sabrina Stücker, Sabrina Stücker, Elisabeth Krämer, Elisabeth Krämer, Frederik Flenner, Frederik Flenner, Giulia Mearini, Giulia Mearini, Julia Münch, Monica Patten, Charles Redwood, Lucie Carrier, Lucie Carrier, Felix W. Friedrich, Felix W. Friedrich   +16 more
doaj   +1 more source

Identification of therapeutic targets for Alzheimer’s Disease Treatment using bioinformatics and machine learning

Scientific Reports
Alzheimer’s disease (AD) is a complex neurodegenerative disorder that currently lacks effective treatment options. This study aimed to identify potential therapeutic targets for the treatment of AD using comprehensive bioinformatics methods and machine ...
ZhanQiang Xie, YongLi Situ, Li Deng, Meng Liang, Hang Ding, Zhen Guo, QinYing Xu, Zhu Liang, Zheng Shao   +8 more
doaj   +1 more source

Comparative Analyses of Gene and Protein Expressions and the Lipid Contents in Intramuscular and Subcutaneous Fat Tissues in Fattening Steers

Animals
In this study, we aimed to characterize intramuscular fat (IMF) tissue in fattening steers through a comparison with subcutaneous fat (SCF) tissue. The IMF of the longissimus thoracis et lumborum and the SCF of the back fat from three fattening steers ...
Kaixi Ji, Ming Yang, Ziying Tan, Hongbo Zhao, Xianglun Zhang   +4 more
doaj   +1 more source

Exocarpium Citri Grandis alleviates postmenopausal obesity in ovariectomized mice through gut microbiota remodeling and metabolic reprogramming

Journal of Functional Foods
Exocarpium Citri Grandis (ECG, Huajuhong), the epicarp of Citrus grandis ‘Tomentosa’, traditionally used to resolve phlegm, is also applied against phlegm-dampness-type obesity.
Tingting Chen, Xiaoqin Wu, Like Xu, Jiaxiong Zhao, Weiru Liu, Jiangtao Zeng, Zhuohui Luo, Jiawen Huang   +7 more
doaj   +1 more source

Keratinizációs zavarok ultrastrukturális és genetikai vizsgálata = Ultrastructural and Genetic Studies in Disorders of Cornification [PDF]

, 2007
Az elmúlt három évben megteremtettük hazánkban a legsúlyosabb örökletes bőrgyógyászati kórképek közt egyes keratinizációs zavarok (pl. társult ichthyosisok, dyskeratosis follicularis) ultrastrukturális és genetikai vizsgálatainak alapjait, lehetővé téve ...
Becker, Krisztina, Kárpáti, Sarolta, Medvecz, Márta, Rácz, Emoke   +3 more
core