Results 51 to 60 of about 2,278 (176)

DOENÇA DE DARIER COMEDÓNICA

Revista da Sociedade Portuguesa de Dermatologia e Venereologia, 2015
A doença de Darier é uma dermatose autossómica dominante causada por uma mutação do gene ATP2A2. Existem várias variantes clínicas menos frequentes nomeadamente as formas de doença de Darier hipertrófica, vesiculobolhosa, hipopigmentada e a variante ...
Tiago Mestre, Fernando Assis Pacheco, António Lázaro, Jorge Cardoso   +3 more
doaj   +1 more source

Computational neuroanatomy and co-expression of genes in the adult mouse brain, analysis tools for the Allen Brain Atlas

, 2013
We review quantitative methods and software developed to analyze genome-scale, brain-wide spatially-mapped gene-expression data. We expose new methods based on the underlying high-dimensional geometry of voxel space and gene space, and on simulations of ...
Grange, Pascal, Hawrylycz, Michael, Mitra, Partha P.   +2 more
core   +1 more source

Increased entropy of signal transduction in the cancer metastasis phenotype [PDF]

, 2010
Studies into the statistical properties of biological networks have led to important biological insights, such as the presence of hubs and hierarchical modularity. There is also a growing interest in studying the statistical properties of networks in the
A Barrat, A Naderi, A Ozgür, A Platzer, AA Samani, AE Teschendorff, AE Teschendorff, AE Teschendorff, AL Barabasi, Andrew E Teschendorff, B Derrida, C Sotiriou, D Pardoll, D Yee, DM Bates, DP Tuck, F Rapaport, H Jeong, H Yu, HY Chuang, I Ulitsky, IW Taylor, J Schäfer, JD Han, JD Storey, JJ Hornberg, K Chin, KR Brown, M Barthelemy, M Neuberg, M Schmidt, MA Pujana, P Farmer, PF Jonsson, RK Nibbe, S Loi, S Negrini, SF Chin, Simone Severini, SL Carter, TS Prasad, U Stelzl, Y Wang   +42 more
core   +5 more sources

Bacteriophage and Fusidic Acid Have Synergistic Effect Against Meticillin‐Resistant Staphylococcus pseudintermedius in Ex Vivo Canine Dermis Model

Veterinary Dermatology, EarlyView.
Background: Antimicrobial stewardship has become vital given the progressive emergence of multidrug‐resistant bacteria, and novel approaches to the treatment of bacterial infections are needed. Recently, reported synergistic effects of antibacterial drugs and bacteriophage therapy have revealed promising applications for the management of meticillin ...
Sarah Ehling, Elisa Peh, Hilke Oltmanns, Jessica Meissner, Sophie Kittler, Christina Puff, Jutta Verspohl, Mathias Müsken, Madeleine Plötz, Andrea Vanessa Volk   +9 more
wiley   +1 more source

Cooccurrence of Darier’s Disease and Epilepsy: A Pediatric Case Report and Review of the Literature

Case Reports in Pediatrics, 2014
Darier’s disease is a skin disorder characterized by multiple eruptions of hyperkeratosis or crusted papules at seborrheic areas with histologic acantholysis and dyskeratosis. It is caused by mutations in a single gene, being ATP2A2 and that is expressed
Tamer Celik, Umit Celik, Cigdem Donmezer, Mustafa Komur, Orkun Tolunay, Pelin Demirtürk   +5 more
doaj   +1 more source

Epilepsie und Morbus Darier - erhöht die Dermatose das Epilepsierisiko? [PDF]

, 2019
Morbus Darier ist eine autosomal-dominant vererbte Hautkrankheit aufgrund von Mutationen in dem Gen ATP2A2, das für eine Ca2+-ATPase (SERCA2) kodiert.
Nolting, Julia Kathinka
core   +1 more source

Efficacy of Der f 2/Zen 1‐LAMP1 Plasmid‐Based Vaccine Immunotherapy in Dogs With Atopic Dermatitis: A Proof‐of‐Concept Study

Veterinary Dermatology, EarlyView.
Background: DNA‐based vaccination rapidly induces strong cellular and humoral immune responses, which may be enhanced by inclusion of lysosomal‐associated membrane protein‐1 (LAMP). Objectives: This proof‐of‐concept study evaluated the efficacy and safety of a Der f 2/Zen 1‐LAMP‐based DNA vaccine immunotherapy in client‐owned dogs with nonseasonal AD ...
Petra Bizikova, Chigusa Matsumoto, Shoji Ogino, Toshihiro Tsukui, Kim Love, Marcy Murphy, Ina Herrmann   +6 more
wiley   +1 more source

Assessing D‐Squame as a Minimally Invasive Technique to Evaluate the Cutaneous Immune Response mRNA in a Dog Model of Canine Atopic Dermatitis

Veterinary Dermatology, EarlyView.
ABSTRACT Background Canine atopic dermatitis (cAD) is a multifactorial, inherited skin disease, estimated to affect ≤ 15% of dogs. Studies of skin messenger mRNA in cAD currently use invasive methods, including blood sampling and biopsy collection, whilst advances in human atopic dermatitis study methodology have demonstrated reliable use of minimally ...
Xavier Langon, Marion Mosca, Nadège Milhau, Mélanie Legain, Adrien Idée, Didier Pin   +5 more
wiley   +1 more source

Inframammary Dermatitis: A Case of Localized Late-Onset Darier’s Disease

Case Reports in Dermatology, 2016
Darier’s disease (DD) is an autosomal dominant inherited genodermatosis which is often under- or misdiagnosed. In the majority of cases, the disease manifests in adolescents or young adults with small brownish-yellow, warty, hyperkeratotic papules in ...
Dennis Linder, Elena Marinello, Pietro Maria Donisi, Roberto Salmaso, Edoardo Zattra, Anna Zampetti   +5 more
doaj   +1 more source

ABCA12 Frameshift Deletion in Domestic Cats With Ichthyosis Fetalis

Veterinary Dermatology, EarlyView.
ABSTRACT Background Ichthyosis fetalis (IF), also known as harlequin ichthyosis, is a rare and often fatal autosomal recessive congenital skin disorder. It is characterized by thickened, hard skin plaques and deep skin fissures that limit mobility and cause malformations of the eyes, lips and ears.
Jeanna M. Blake, Melissa P. Swan, Kari J. Ekenstedt   +2 more
wiley   +1 more source