Results 181 to 190 of about 12,888 (214)

The pea mitochondrial atp6: RNA editing and similarity of presequences in the Vicieae tribe

Current Genetics, 2004
The atp6 gene has been identified as a single-copy sequence in the mitochondrial genome of the pea. An unexpected finding concerns the atp6 5' extension which is known to be poorly conserved at the sequence level, even between closely related plant species.
Hanna Jańska
exaly   +3 more sources

Hypocitrullinemia as an Early Diagnostic Biomarker for MT-ATP6 Mitochondrial Diseases

Journal of Molecular Neuroscience
MT-ATP6 mitochondrial diseases are a group of disorders inherited from the maternal lineage caused by pathogenic variants in the MT-ATP6 gene, which encodes the a subunit of mitochondrial complex V (ATP synthase) in the electron transport chain. In this study, statistical analysis of 69 mitochondrial disease patients with complete blood metabolic ...
Dongjuan Wang, Siqi Hong
exaly   +3 more sources

Genetic Diversity of atp6 and cox3 Gene in Wild Drosophila melanogaster

Russian Journal of Genetics, 2019
Mitochondria are the energy factory in cells, and more than 95% of the energy in cells is produced by the mitochondrial oxidative phosphorylation (OXPHOS). Therefore, mitochondria likely plays an important role in the process of high-altitude adaptation.
Chen, M., Yin, H., Gu, H., Zhang, L., Xu, Z.X., Ma, T., Li, D.   +6 more
openaire   +2 more sources

Allotopic Expression of ATP6 in Mouse as a Transgenic Model of Mitochondrial Disease

2015
Progress in animal modeling of polymorphisms and mutations in mitochondrial DNA (mtDNA) is not as developed as nuclear transgenesis due to a host of cellular and physiological distinctions. mtDNA mutation modeling is of critical importance as mutations in the mitochondrial genome give rise to a variety of pathological conditions and play a contributing
David A, Dunn, Carl A, Pinkert
openaire   +3 more sources

GUG is an efficient initiation codon to translate the human mitochondrial ATP6 gene

Biochemical and Biophysical Research Communications, 2004
A maternally inherited and practically homoplasmic mitochondrial (mtDNA) mutation, 8527A>G, changing the initiation codon AUG into GUG, normally coding for a valine, was observed in the ATP6 gene encoding the ATPase subunit a. No alternate Met codon could replace the normal translational initiator. The patient harboring this mutation exhibited clinical
A, Dubot, C, Godinot, V, Dumur, B, Sablonnière, T, Stojkovic, J M, Cuisset, A, Vojtiskova, P, Pecina, P, Jesina, J, Houstek   +9 more
openaire   +2 more sources

Sequence analysis of the wheat mitochondrial atp6 gene reveals a fused upstream reading frame and markedly divergent N termini among plant ATP6 proteins

Gene, 1988
The nucleotide sequence of the wheat mitochondrial gene for subunit 6 (atp6) of the F1F0 ATPase complex has been determined. Unlike bacterial, chloroplast or animal/fungal mitochondrial atp6 counterparts, which encode proteins of about 230-270 amino acids, the wheat mitochondrial atp6 homologue comprises the latter part of an open reading frame (ORF ...
L, Bonen, S, Bird
openaire   +2 more sources

Mitochondrial ATP6 and ND3 genes are associated with type 2 diabetic peripheral neuropathy

Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 2022
The association of mitochondrial NADH dehydrogenase gene mutations with type 2 diabetes in the Karaikudi population was previously reported. This is a case report that demonstrated rare mutations are responsible for maternally inherited peripheral neuropathy of diabetes.We describe a 70-year-old male and his family (n = 25) with type 2 diabetic ...
Devi Kasinathan, Khalid Matrougui, Santhini Elango, Souad Belmandani, Balaji Srinivas, Karthikeyan Muthusamy, Prabhu Narayanasamy Marimuthu   +6 more
openaire   +2 more sources

Mitochondrial atp6 transcript editing during microgametogenesis in male-sterile sorghum

Current Genetics, 2001
A marked reduction of mitochondrial atp6 transcript-editing capability in sorghum anthers and pollen has been invoked as a factor in the loss of viability of male gametophytes in lines carrying the IS1112C male-sterile cytoplasm. We initiated a systematic examination of transcript editing of sorghum atp6 during microgametogenesis, from microspores ...
D R, Pring, H, Van Tang
openaire   +2 more sources

Analysis of silent RNA editing sites in atp6 transcripts of Sorghum bicolor

Current Genetics, 1995
We have observed numerous examples of silent or rare non-silent editing sites in the amino-extension and part of the conserved core of mitochondrial atp6 transcripts of Sorghum. In this region of the 1.4-kb atp6-2 mRNA (position 300 to 550) two editing sites, which alter the amino-acid sequence and occur in all cDNAs analysed, were already known, while
F, Kempken, G, Höfken, D R, Pring
openaire   +2 more sources

Diversities in Leigh Syndrome Associated with MT-ATP6 Gene Variants

Endocrine, Metabolic & Immune Disorders - Drug Targets
Introduction:: Leigh syndrome (LS) is clinically and genetically heterogeneous and presents defective mitochondrial bioenergetics. Patients present neurological symptoms and imagiological features that may result in early death [1].
Sara, Martins, Maria João, Santos, Marta, Simões, Sandra, Jacinto, Cristina, Martins Halpern, Juliette, Dupont, Luísa, Diogo, Manuela, Grazina   +7 more
openaire   +2 more sources