Results 121 to 130 of about 12,983 (164)

Interaction and Joint Effects of Inflammation and Triglyceride–Glucose (TyG) Index on Hyperuricemia Risk and the Mediating Role of TyG: A Cross‐Sectional Study

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 3, May 2026.
Among 5307 southern Chinese adults, higher TyG index and mINFLA score were associated with increased HUA risk and serum UA levels (p trend < 0.001). A significant interaction was observed between these two indicators. Notably, the TyG index mediated 15.4% of the mINFLA‐HUA association and 14.5% of the mINFLA‐UA association.
Xueran Huang, Pengfei Chen, Yongfen Gao, Zengnan Mo, Haiying Zhang, Rui Lin   +5 more
wiley   +1 more source

Maternal Chrono‐Nutrition and Placental DNA Methylation: The BiSC Study

Molecular Nutrition &Food Research, Volume 70, Issue 9, 13 May 2026.
This is the first study to examine how the timing of a mother's meals during pregnancy relates to changes in placental DNA methylation, an epigenetic mark. We found that the timing of the last daily meal was most important. Some epigenetic changes were linked to genes involved in placental function and development, and the long‐term health consequences
Joana Llauradó‐Pont, Sofia Aguilar‐Lacasaña, Marta Cosin‐Tomas, Jordi Julvez, Oren Contreras‐Rodríguez, Manolis Kogevinas, Kyriaki Papantoniou, Elisa Gallo, Barbara N Harding, Martine Vrijheid, Payam Dadvand, Mariona Bustamante, Camille Lassale   +12 more
wiley   +1 more source

cRGD-Functionalized macrophage extracellular vesicles loaded with GSK2033 enhance T cell antitumor immunity in GBM by disrupting the LXR/ABCA1-Mediated Myelin lipid transfer axis

Journal of Nanobiotechnology
Glioblastoma (GBM), the most aggressive adult primary brain tumor, faces lethal challenges due to its immunosuppressive microenvironment and blood-brain barrier (BBB) impedance.
Changlong Bi, Song Lan, Zhongyi Sun, Fan Fan, Xiangying Luo   +4 more
doaj   +1 more source

Serum Proteomic Analysis Using Gel‐Based Liquid Chromatography Tandem Mass Spectrometry Reveals Differences Between Canine Oral Malignancies and Non‐Malignant Conditions

Veterinary Medicine and Science, Volume 12, Issue 3, May 2026.
This study establishes a GeLC‐MS/MS‐based serum proteomics workflow for canine oral oncology to differentiate malignancies from non‐malignant conditions. Comprehensive protein profiling, pathway analysis and protein–drug interaction mapping reveal candidate biomarkers and insights into the pathogenesis of canine oral cancers.
Sekkarin Ploypetch, Sittiruk Roytrakul, Janthima Jaresitthikunchai, Narumon Phaonakrop, Gunnaporn Suriyaphol   +4 more
wiley   +1 more source

The Arsenal of Aromatic Degrading Bacteria: How They Sense, Chase, Adapt and Destroy Environmental Pollutants

Microbial Biotechnology, Volume 19, Issue 5, May 2026.
In the environment, bacteria sense aromatic pollutants, migrate toward them, adapt to toxicity, and deploy specialized uptake and catabolic systems. Genomic plasticity, metabolic versatility and division of labor within populations together aid in the degradation of persistent aromatics, highlights that biodegradation is driven by various eco ...
Prashant S. Phale, Tushar Dhamale, Satyajit Subhash   +2 more
wiley   +1 more source

Exceptional Longevity Modifying Allele APOE2 Promotes DNA Signaling Pathways Resisting Cellular Senescence in Human Neurons

Aging Cell, Volume 25, Issue 5, May 2026.
Neurons expressing APOE2 were more resistant to endogenous DNA damage, activated transcriptional signaling pathways associated with DNA repair, and were resilient to stress‐induced DNA damage and cellular senescence. In contrast, APOE4 neurons exhibited elevated expression of rRNA repetitive elements and were prone to becoming senescent.
Cristian Gerónimo‐Olvera, Stephen M. Scheeler, Carlos Galicia Aguirre, Genesis Vega‐Hormazabal, Daniela Garcia, Long Wu, Natalia Murad, Kevin Schneider, Kenneth A. Wilson, Nikola T. Markov, Sicheng Song, Jesse Simons, Akos A. Gerencser, Emily Parlan, Sean D. Mooney, Eric Verdin, Judith Campisi, Tara E. Tracy, David Furman, Simon Melov, Lisa M. Ellerby   +20 more
wiley   +1 more source

Upregulation of sphingomyelin and ABCA8 in response to TDP‐43 pathology in amyotrophic lateral sclerosis brain

Brain Pathology, Volume 36, Issue 3, May 2026.
Increases in sphingomyelin in response to TDP‐43 pathology in the disease‐affected motor cortex of amyotrophic lateral sclerosis (ALS) brain. Abstract Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative disease characterized by the degeneration of motor neurons and the presence of TAR DNA‐binding protein 43 (TDP‐43 ...
Finula I. Isik, Russell Pickford, Nicolas Dzamko, Kerry‐Anne Rye, Woojin Scott Kim   +4 more
wiley   +1 more source

The Hemoprotein Hhy1 Promotes Heme‐Dependent Catalase Activity of Ctt1

Molecular Microbiology, Volume 125, Issue 5, Page 389-411, May 2026.
A Schizosaccharomyces pombe strain deficient in heme (hem1Δ) and siderophore (Fc) biosynthesis, as well as high‐affinity iron (Fe) uptake (blue), was used to uncover the hemoprotein Hhy1 that promotes the heme‐dependent activity of the catalase Ctt1. In contrast, hhy1Δ cells exhibit reduced Ctt1 activity and increased sensitivity to oxidative stress ...
Tobias Vahsen, Samuel Plante, Berthy Mbuya, Simon Labbé   +3 more
wiley   +1 more source

The Arabidopsis NPF7.2 mediates coumarin uptake for root iron acquisition

New Phytologist, Volume 250, Issue 3, Page 1619-1633, May 2026.
Summary Iron (Fe) is a transition metal necessary for achieving essential physiological processes throughout the plant lifecycle. In Arabidopsis thaliana, secreting Fe‐mobilizing coumarins (FMC) is a key mechanism enabling roots to acquire nonbioavailable Fe present in soils.
Shunsuke Watanabe, Meijie Li, Alice Rossille, Chérhazad Boustani, Kevin Robe, Yuri Kanno, Mitsunori Seo, Christian Dubos   +7 more
wiley   +1 more source

OsMT2b Regulates Pollen Development and ROS Homeostasis in a Photoperiod‐Dependent Manner

Plant Biotechnology Journal, Volume 24, Issue 5, Page 3051-3064, May 2026.
ABSTRACT Reactive oxygen species (ROS) are signalling molecules that promote programmed cell death in animal and plant systems. However, their role in rice (Oryza sativa L.) anther development is unclear. In this study, we show that lower transcript levels of the metallothionein gene OsMT2b in japonica rice plants obtained by RNA interference (RNAi ...
Ying He, Can Wang, Zilong Luo, Mingyang Ding, Yunyi Wen, Jiao Liu, Weiting Chen, Jing Li, Chuxiong Zhuang, Dagang Jiang   +9 more
wiley   +1 more source