Results 251 to 260 of about 115,582 (346)

Indocyanine green clearance's association with liver function in paediatric liver disease

open access: yesActa Paediatrica, Volume 114, Issue 5, Page 980-985, May 2025.
Abstract Aim Indocyanine green (ICG) clearance, a sensitive biomarker for liver function, has not been validated in children. We assessed the association between ICG clearance and liver function in children with liver disease. Methods ICG plasma disappearance rate (ICG‐PDR, %/min) was measured in children with liver disease. Mixed linear regression was
G. Ficerai‐Garland   +10 more
wiley   +1 more source

Complex trajectories are associated with neurological impairment in infants with congenital gastrointestinal malformations aged two

open access: yesActa Paediatrica, Volume 114, Issue 5, Page 992-998, May 2025.
Abstract Aim Our aims were to describe the neurodevelopment of infants with congenital gastrointestinal malformations at 2 years of age and to investigate the association between developmental delay and complex trajectories. Methods We conducted a retrospective cohort study.
Manon Midavaine   +4 more
wiley   +1 more source

Perioperative Airway Management for Midface Surgery in Children With Syndromic Craniosynostosis; a Single Center Experience With Immediate Extubation

open access: yesPediatric Anesthesia, Volume 35, Issue 5, Page 380-388, May 2025.
ABSTRACT Background Midface advancements in children with syndromic craniosynostosis present challenges for anesthesiologists and intensive care teams. Aims This study reviewed the perioperative airway management protocol for immediate tracheal extubation after midface surgery at our tertiary center over the past 10 years.
Iris E. Cuperus   +6 more
wiley   +1 more source

Elevated Linoleic Acid Intake Becomes a Risk Factor for Polycystic Ovary Syndrome by Affecting Ovarian Granulosa Cells

open access: yesThe FASEB Journal, Volume 39, Issue 7, 15 April 2025.
This study explored the relationship between dietary LA intake and PCOS. Animal experiments demonstrated that increased intake of LA led to PCOS‐like changes in mice, presenting with disordered estrous cycles, polycystic ovaries, and hyperandrogenism.
Wenying Zhang, Fuju Wu
wiley   +1 more source

CRISPR targeting of FOXL2 c.402C>G mutation reduces malignant phenotype in granulosa tumor cells and identifies anti‐tumoral compounds

open access: yesMolecular Oncology, Volume 19, Issue 4, Page 1092-1116, April 2025.
FOXL2 c.402C>G mutation drives granulosa cell tumors. Using CRISPR technology, we selectively corrected this mutation, reducing malignancy and increasing sensitivity to dasatinib and ketoconazole. Transcriptomic changes revealed potential therapeutic targets, demonstrating CRISPR's promise for treating this rare ovarian cancer.
Sandra Amarilla‐Quintana   +17 more
wiley   +1 more source

Congenital Titinopathy: Comprehensive Characterization of the Most Severe End of the Disease Spectrum

open access: yesAnnals of Neurology, Volume 97, Issue 4, Page 611-628, April 2025.
Congenital titinopathy has recently emerged as one of the most common congenital muscle disorders. Objective To better understand the presentation and clinical needs of the under‐characterized extreme end of the congenital titinopathy severity spectrum.
Sandra Coppens   +71 more
wiley   +1 more source

Impact of fetal treatments for congenital diaphragmatic hernia on lung development

open access: yesThe Anatomical Record, Volume 308, Issue 4, Page 1066-1081, April 2025.
Abstract The extent of lung hypoplasia impacts the survival and severity of morbidities associated with congenital diaphragmatic hernia (CDH). The alveoli of CDH infants and in experimental models of CDH have thickened septa with fewer type II pneumocytes and capillaries. Fetal treatments of CDH‐risk preterm birth.
Mar Janna Dahl   +5 more
wiley   +1 more source

Relating normal human cardiac development to the anatomical findings in the congenitally malformed heart

open access: yesClinical Anatomy, Volume 38, Issue 3, Page 296-313, April 2025.
Abstract A proper appreciation of cardiac development can now provide the necessary background to understand the anatomical findings in the congenitally malformed heart. We recently presented an account of human cardiac development based on reconstructions of histological datasets from human embryos aged between 3.5 and 8 weeks subsequent to conception.
Jill P. J. M. Hikspoors   +5 more
wiley   +1 more source

Home - About - Disclaimer - Privacy