Results 71 to 80 of about 4,501 (176)

New Perspective in Atrial Fibrillation [PDF]

, 2022
In spite of the large volume of associated research, the pathophysiological mechanisms involved in atrial fibrillation (AF) onset and recurrence remain uncertain.

core   +1 more source

Cerebral Infarction: Epidemiology, Classification, Mechanisms, Diagnosis, and Management

MedComm, Volume 7, Issue 4, April 2026.
Within minutes after ischemia onset, deprivation of oxygen and glucose leads to rapid ATP depletion, resulting in failure of Na+/K+‐ATPase activity and membrane depolarization. This ionic imbalance promotes uncontrolled synaptic release of glutamate and excessive activation of postsynaptic NMDA and AMPA receptors.
Meibiao Zhang, Jianxun Hou, Jia Kuang, Lei Hao, Zhao Yang   +4 more
wiley   +1 more source

Non-stenotic Carotid Plaques in Embolic Stroke of Unknown Source

Frontiers in Neurology, 2021
Embolic stroke of unknown source (ESUS) represents one in five ischemic strokes. Ipsilateral non-stenotic carotid plaques are identified in 40% of all ESUS.
Joseph Kamtchum-Tatuene, Ali Z. Nomani, Sarina Falcione, Danielle Munsterman, Gina Sykes, Twinkle Joy, Elena Spronk, Maria Isabel Vargas, Glen C. Jickling   +8 more
doaj   +1 more source

Hypertrophic Cardiomyopathy as a Key Feature of MRAS‐Related Noonan Syndrome: New Case and Comprehensive Literature Review

Prenatal Diagnosis, Volume 46, Issue 4, Page 581-588, April 2026.
ABSTRACT Noonan syndrome (NS) is a rare multisystemic condition among the RASopathy group, characterized by a broad phenotypic spectrum and genetic variability. It results from pathogenic variants in genes regulating the RAS/MAPK pathway, affecting cell proliferation and differentiation.
Romain Martineau, Constance Wells, Florent Fuchs, Sophie Collardeau‐Frachon, Valentin Ruault, Sophie Colomb, Jean‐Michel Faure, Caroline Bartholmot, Marie Vincenti, Benjamin Ganne, Marjolaine Willems   +10 more
wiley   +1 more source

Relationship between left atrial volume and ischemic stroke subtype

Annals of Clinical and Translational Neurology, 2019
Objective Atrial cardiopathy without atrial fibrillation (AF) may be a potential cardiac source of embolic strokes of undetermined source (ESUS). Atrial volume is a feature of atrial cardiopathy, but the relationship between atrial volume and ESUS ...
Hooman Kamel, Peter M. Okin, Alexander E. Merkler, Babak B. Navi, Thomas R. Campion, Richard B. Devereux, Iván Díaz, Jonathan W. Weinsaft, Jiwon Kim   +8 more
doaj   +1 more source

Prevalence and Overlap of Potential Embolic Sources in Patients With Embolic Stroke of Undetermined Source

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background We aimed to assess the prevalence and degree of overlap of potential embolic sources (PES) in patients with embolic stroke of undetermined source (ESUS).
George Ntaios, Kalliopi Perlepe, Dimitrios Lambrou, Gaia Sirimarco, Davide Strambo, Ashraf Eskandari, Efstathia Karagkiozi, Anastasia Vemmou, Eleni Koroboki, Efstathios Manios, Konstantinos Makaritsis, Konstantinos Vemmos, Patrik Michel   +12 more
doaj   +1 more source

Oral anticoagulation in elderly patiens as secondary prevention of cardioembolic strokes [PDF]

, 2010
Background: Stroke incidence increases with age. Atrial fibrillation (AF) is an important risk factor for ischemic stroke and its incidence also increases with age. However oral anticoagulant therapy (OAT) tends to be underused in the elderly population.
Benavente, Lorena, Calleja, Sergio, García, Jorge, H Lahoz, Carlos, Vega, Vanessa   +4 more
core  

Prohormones in the early diagnosis of cardiac syncope [PDF]

, 2017
Background--The early detection of cardiac syncope is challenging. We aimed to evaluate the diagnostic value of 4 novel prohormones, quantifying different neurohumoral pathways, possibly involved in the pathophysiological features of cardiac syncope ...
Badertscher, Patrick, Boeddinghaus, Jasper, Buser, Andreas, Bustamante, José, Christ, Michael, Cullen, Louise, de Lavallaz, Jeanne du Fay, Di Somma, Salvatore, Flores, Dayana, Frank Peacock, W., Geigy, Nicolas, Giménez, Maria Rubini, Javier Martin-Sanchez, F., Kawecki, Damian, Keller, Dagmar I., Kloos, Wanda, Kozhuharov, Nikola, Kuehne, Michael, Lohrmann, Jens, López, Beatriz, Miró, Oscar, Morawiec, Beata, Mueller, Christian, Nestelberger, Thomas, Osswald, Stefan, Poepping, Imke, Puelacher, Christian, Reichlin, Tobias, Rentsch, Katharina, Sabti, Zaid, Sarasin, François, Shrestha, Samyut, Strebel, Ivo, Than, Martin, Tschuck, Michael, Twerenbold, Raphael, Wildi, Karin   +36 more
core   +1 more source

Mitochondrial Ca2+ overload is a pivotal risk factor for lethal ventricular arrhythmias due to the oxidation of mitochondrial respirasome and energetic failure

British Journal of Pharmacology, Volume 183, Issue 7, Page 1404-1426, April 2026.
The data that support the findings of this study are available from the corresponding author upon reasonable request. Some data may not be made available because of privacy or ethical restrictions. Background and Purpose Ventricular arrhythmias are a leading cause of death among patients with cardiovascular diseases and are associated with elevated ...
Felipe de Jesús Salazar‐Ramírez, Luis Alberto Luévano‐Martínez, Abraham Méndez‐Fernández, Judith Bernal‐Ramírez, Carolina A. Morales‐Ochoa, Christian Silva‐Platas, Alfredo Cabrera‐Orefice, Ana C. Murrieta, José Luis Velasco‐Bolom, Gricelda Mendiola‐Garza, Flavio Contreras‐Torres, Guillermo Torre‐Amione, Ernesto A. Aiello, Gerardo García‐Rivas   +13 more
wiley   +1 more source

Expansion of the Phenotypic and Genotypic Spectrum for PRKAR1B ‐Related Marbach–Schaaf Neurodevelopmental Syndrome: A Case Series

Clinical Genetics, Volume 109, Issue 4, Page 679-696, April 2026.
Comprehensive clinical description of 12 subjects with pathogenic PRKAR1B variants, including two heterozygous deletions supporting haploinsufficiency as a possible mechanism of disease, providing valuable insight into the pathophysiology of MASNS and setting a framework upon which to design future mechanistic studies of PKA signaling in brain ...
Sebastian Burkart, Tarik Guzeloglu, Ana R. Soares, Irene Valenzuela, Eduardo F. Tizzano, David Gómez‐Andres, Laurent Pasquier, Marine Legendre, Camille Berges, Julien Thevenon, Marjolaine Gauthier, Caleb Heid, Elly Ranum, Joseph Shen, Michelle Frees, Michael W. Schmidtke, Caro Pilar, Christian P. Schaaf   +17 more
wiley   +1 more source