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The Role of Atrial Fibrosis for Atrial Fibrillation: Not Always Essential?
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Atrial fibrosis progression in patients with no history of atrial fibrillation
Journal of Cardiovascular Electrophysiology, 2021AbstractBackgroundUnexpected high levels of atrial fibrosis are found in individuals with no history of atrial fibrillation (AF). The temporal behavior of atrial fibrosis in this population is still unknown. We sought to investigate the progression and predictors of atrial fibrosis in non‐AF individuals.MethodsNon‐AF individuals at baseline who ...
Lilas Dagher +8 more
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Assessment of atrial fibrosis for the rhythm control of atrial fibrillation [PDF]
Rhythm control of atrial fibrillation (AF) remains challenging, with modest long-term success rates. Atrial fibrosis has been associated with AF, but the clinical utility of assessment of this fibrosis has yet to be fully elucidated. In this paper we review the current state of understanding of the pathophysiology of atrial fibrosis in AF, and its ...
Gordon A Begg +2 more
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Atrial fibrosis: a risk stratifier for atrial fibrillation
Expert Review of Cardiovascular Therapy, 2013Atrial fibrillation (AF), especially persistent and long-standing persistent AF, may result in electro-anatomical changes in the left atrium, resulting in remodeling and deposition of fibrous tissue. There are emerging data that atrial substrate modification may increase the risk of thromboembolic complications, including stroke.
Poonam, Velagapudi +3 more
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Atrial Arrhythmias in Endomyocardial Fibrosis
Cardiology, 1972Atrial arrhythmias occurred in 34 out of 97 patients with endomyocardial fibrosis. In 21 instances, atrial fibrillation or flutter was persistent. In 13 cases, atrial arrhythmia was transient and intermittent. It was necessary, in some patients with rapid ventricular re sponses, to employ direct-current cardioversion.
K, Somers +3 more
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An Atrial fibrosis-based Approach for Atrial Fibrillation Ablation
Future Cardiology, 2015Since the emergence of atrial fibrillation (AF) ablation as a reliable method of restoring sinus rhythm, various approaches have been used to improve the efficacy while maximizing the safety of ablation. A major hurdle to optimizing outcomes for AF ablation has been the failure to recognize that the substrate of the individual patient plays a ...
Frederick T, Han, Nassir, Marrouche
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EZH2 as a novel therapeutic target for atrial fibrosis and atrial fibrillation
Journal of Molecular and Cellular Cardiology, 2019Angiotensin II (Ang-II)-induced fibroblast differentiation plays an important role in the development of atrial fibrosis and atrial fibrillation (AF). Here, we show that the expression of the histone methyltransferase enhancer of zeste homolog 2 (EZH2) is increased in atrial muscle and atrial fibroblasts in patients with AF, accompanied by significant ...
Bin-Feng Mo, Long Chen, Guojian Fang
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Left Atrial Fibrosis and Recurrent Arrhythmia
JAMA, 2014In the Delayed-Enhancement MRI Determinant of Successful Radiofrequency Catheter Ablation of Atrial Fibrillation (DECAAF) study, Dr Marrouche and colleagues1 demonstrated that assessment of left atrial fibrosis with delayed enhancement magnetic resonance imaging (MRI) was associated with the likelihood of recurrent arrhythmia after catheter ablation ...
Tops, L.F., Schalij, M.J.
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