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Life Sciences, 1985
Mammalian atria contain different peptides with potent diuretic, natriuretic, smooth muscle relaxing and blood pressure lowering properties. A preprohormone of these peptides is synthetized and stored in specific granules in atrial myocytes. Different peptides have been isolated, analyzed and in vitro synthetized.
Wolfram Gaida +2 more
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Mammalian atria contain different peptides with potent diuretic, natriuretic, smooth muscle relaxing and blood pressure lowering properties. A preprohormone of these peptides is synthetized and stored in specific granules in atrial myocytes. Different peptides have been isolated, analyzed and in vitro synthetized.
Wolfram Gaida +2 more
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The Atrial Natriuretic Factor in Hypertension
Mayo Clinic Proceedings, 1988Plasma immunoreactive atrial natriuretic factor (IR-ANF) concentration measured by radioimmunoassay after extraction on Sep-Pak cartridges was studied in 64 control normotensive subjects, 25 patients with labile essential hypertension, 67 patients with mild essential hypertension (diastolic pressure between 90 and 105 mm Hg and no left ventricular ...
Raul Garcia +5 more
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Atrial Natriuretic Factor Receptors
Endocrinology and Metabolism Clinics of North America, 1987All of the actions of atrial natriuretic factor (ANF) can be explained on the basis of ANF's interaction with specific receptors on the plasma membrane of cells in target tissues. These receptors have been identified. Binding to these receptors by ANF is time dependent and specific and occurs with high affinity.
John W. Jacobs +2 more
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The Heart and the Atrial Natriuretic Factor*
Endocrine Reviews, 1985The search for natriuretic hormones or factors by studies of negative pressure breathing, atrial distension experiments, head-out water immersion, expansion of blood volume, Na+/K+-ATPase inhibitors and parabiosis experiments in Dahl rats has led to the finding that the atria are a peptide-secreting endocrine gland. This new natriuretic hormone has now
Marc Cantin, Jacques Genest
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Receptors of Atrial Natriuretic Factor
Annual Review of Physiology, 1992Atrial natriuretic factor (ANF) is a polypeptide hormone that is secreted mainly by the heart atria in response to increases in atrial pressure or atrial stretch. ANF has multiple actions in the kidney that lead to increases in glomerular filtration rate and excretion of fluid and electrolytes, modulation of renal vascular resistance, decreases in ...
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Direct radioimmunoassay of atrial natriuretic factor
Biochemical and Biophysical Research Communications, 1984A direct radioimmunoassay of atrial natriuretic factor (ANF) has been developed. The method uses a synthetic 26 amino-acid fragment (8-33 ANF) of the native peptide. Antibodies have been prepared in rabbits immunized with the peptide coupled to thyroglobulin.
Gaétan Thibault +4 more
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The physiology of atrial natriuretic factor
Canadian Journal of Physiology and Pharmacology, 1987Following the discovery of the natriuretic effect of atrial extract, our laboratory attempted to dissect the possible physiological role of atrial natriuretic factor. Initial micropuncture experiments demonstrated that the reduction of tubular sodium reabsorption was localized in the medullary collecting duct, a nephron site in which sodium transport ...
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Release of atrial natriuretic factor
Scandinavian Journal of Clinical and Laboratory Investigation, 1993The cardiac atria synthesize and store a hormone termed atrial natriuretic factor (ANF). ANF is released into the systemic circulation, and the circulating 28 amino acid peptide can be measured by radioimmunoassay. The hormone participates in body fluid homeostasis through its effect on renal sodium excretion and by inducing a shift of circulating ...
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Atrial Natriuretic Factor in Gynecologic Malignancy
Obstetrics & Gynecology, 1995To determine whether plasma atrial natriuretic factor (ANF) levels are different in patients with gynecologic malignancy compared with those in healthy, nonpregnant women, and if differences do exist, whether chemotherapy plays a role.We compared the plasma levels of ANF in nonpregnant women free of malignancy (group 1, n = 25) and in patients with ...
Papineni S. Rao +5 more
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