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Thirty years of research on atrial natriuretic factor: historical background and emerging concepts.
Canadian Journal of Physiology and Pharmacology, 2011The discovery of the natriuretic properties of atrial muscle extracts pointed to the existence of an endocrine function of the heart that is now known to be mediated by the polypeptide hormones atrial natriuretic factor (ANF) and brain natriuretic ...
A. D. de Bold
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Effects of synthetic atrial natriuretic factor on renal function and renin release.
American Journal of Physiology, 1984Studies were performed in anesthetized dogs (n = 5) to determine the effects of synthetic atrial natriuretic factor on renal function and renin release.
John C. Burnett +2 more
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Circulation Research, 1988
The current studies were designed to investigate the mechanisms in the intact anesthetized dog that control the release of atrial natriuretic factor (ANF). In vitro, mechanical stretch of atrial tissue produces an increased release of ANF.
Brooks S. Edwards +4 more
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The current studies were designed to investigate the mechanisms in the intact anesthetized dog that control the release of atrial natriuretic factor (ANF). In vitro, mechanical stretch of atrial tissue produces an increased release of ANF.
Brooks S. Edwards +4 more
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Effect of a purified atrial natriuretic factor on rat and rabbit vascular strips and vascular beds.
American Journal of Physiology, 1984Rat atrium cardiocytes contain a powerful natriuretic and diuretic peptide that has been localized in the specific granules. This atrial natriuretic factor (ANF) produced a potent, dose-dependent relaxant effect on rabbit and rat arterial strips ...
R. Garcia +3 more
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Atrial Natriuretic Factor Receptors
Endocrinology and Metabolism Clinics of North America, 1987All of the actions of atrial natriuretic factor (ANF) can be explained on the basis of ANF's interaction with specific receptors on the plasma membrane of cells in target tissues. These receptors have been identified. Binding to these receptors by ANF is time dependent and specific and occurs with high affinity.
John W. Jacobs +2 more
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Journal of Clinical Endocrinology and Metabolism, 1985
We studied the effects of a bolus injection of 50/micrograms synthetic human atrial natriuretic factor (ANF) on the cyclic GMP and cyclic AMP levels in plasma and urine of eight normal men. Administration of the hormone increased basal immunoreactive (IR-
R. Gerzer +4 more
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We studied the effects of a bolus injection of 50/micrograms synthetic human atrial natriuretic factor (ANF) on the cyclic GMP and cyclic AMP levels in plasma and urine of eight normal men. Administration of the hormone increased basal immunoreactive (IR-
R. Gerzer +4 more
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Nucleotide sequences of the human and mouse atrial natriuretic factor genes.
Science, 1984Mouse and human atrial natriuretic factor (ANF) genes have been cloned and their nucleotide sequences determined. Each ANF gene consists of three coding blocks separated by two intervening sequences.
C. Seidman +4 more
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HYPERTENSION, 1984
We have previously shown that the natriuretic effect of rat atrial extract (AE) may be due, perhaps entirely, to its powerful renal hemodynamic actions. The present study was undertaken to test the hypothesis that mammalian atria contain a substance that
H. Kleinert +5 more
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We have previously shown that the natriuretic effect of rat atrial extract (AE) may be due, perhaps entirely, to its powerful renal hemodynamic actions. The present study was undertaken to test the hypothesis that mammalian atria contain a substance that
H. Kleinert +5 more
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Receptors of Atrial Natriuretic Factor
Annual Review of Physiology, 1992Atrial natriuretic factor (ANF) is a polypeptide hormone that is secreted mainly by the heart atria in response to increases in atrial pressure or atrial stretch. ANF has multiple actions in the kidney that lead to increases in glomerular filtration rate and excretion of fluid and electrolytes, modulation of renal vascular resistance, decreases in ...
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Synthetic rat atrial natriuretic factor inhibits in vitro and in vivo renin secretion in rats.
Endocrinology, 1985We investigated the action of a synthetic rat atrial natriuretic factor (ANF) with 28 amino acids on renin secretion in rats. Renin release by kidney cortex slices was determined after 90 min of incubation at 37C.
K. Obana +6 more
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