The Journal of Physiology, EarlyView.Abstract figure legend This randomized cross‐over trial (N = 12) addressed the hypothesis that selective reduction of pulmonary arterial pressure (i.e. manipulation of pulmonary arterial mechanoreceptor activation) during hypoxic exercise would reduce sympathetic outflow (muscle sympathetic nerve activity (MSNA)) in healthy humans.
Michiel T. Ewalts +9 more
wiley +1 more source
Mitochondrial haplotype and sex modulate responses to endurance exercise training
The Journal of Physiology, EarlyView.Abstract figure legend Using OKC‐HETB/W rats we demonstrate that mitochondrial haplotype influences training responses of endurance exercise. Overall OKC‐HETW rats showed greater responses than OKC‐HETB in exercise tolerance, mitochondrial bioenergetics, mitochondrial DNA (mtDNA) mutation frequencies and motor co‐ordination.
Bumsoo Ahn +8 more
wiley +1 more source
The physiology of lived experiences: A hole in the heart and the dive that found it
Experimental Physiology, EarlyView.
James E. Clark
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Traditional planar imaging approaches of the left atrium do not capture complex geometry. Four‐dimensional imaging allows the acquisition of 3D data + time to visualize left atrial geometry and kinematics. We designed an advanced analysis technique to investigate left atrial biomechanics in a model of pressure overload and ...
John P. Salvas +3 more
wiley +1 more source
Left ventricular and atrial strain and the risk of mortality and rehospitalization in heart failure. [PDF]
Echo Res PractZilic H +4 more
europepmc +1 more source
Computational model of haemodynamics during atrial fibrillation
The Journal of Physiology, EarlyView.Abstract figure legend We developed a simplified computational model that replicates patient‐specific haemodynamics during both normal sinus rhythm and atrial fibrillation (AF). Our computational model comprises: (1) an electrical subsystem that generates unco‐ordinated atrial and irregular ventricular activation times characteristic of AF and (2) a ...
Felix Plappert +7 more
wiley +1 more source
Influence of left bundle branch block on left atrial strain parameters in patients with ischaemic and non-ischaemic dilated cardiomyopathy. [PDF]
Int J Cardiovasc ImagingPetersen A +5 more
europepmc +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend The capillary–mitochondria–ion channel (CMIC) axis scales structural resources to match functional workload. (Left) In settings of restricted energetic capacity (e.g. cortical neurons), sparse capillary networks and modest mitochondrial pools set a lower energetic ceiling, sufficient to support phasic, low‐workload excitability. (
L. Fernando Santana, Scott Earley
wiley +1 more source
Association of Left Atrial Strain With One-Year Clinical Outcomes in Patients Hospitalized With Acute Decompensated Heart Failure With Preserved Ejection Fraction. [PDF]
CureusBrigic L, Džubur A, Dervišević L.
europepmc +1 more source
Caenorhabditis elegans as an in vivo model system for human inherited primary arrhythmia syndromes
The Journal of Physiology, EarlyView.Abstract figure legend Most genes involved in inherited primary arrhythmia syndromes (IPAS) are conserved in Caenorhabditis elegans, where genetic manipulation enables functional characterization of variants, identification of regulatory proteins, and in vivo drug testing.
Antoine Delinière +6 more
wiley +1 more source