Results 41 to 50 of about 1,454,735 (293)

Left atrial contraction strain and controlled preload alterations, a study in healthy individuals

Cardiovascular Ultrasound, 2022
Background In order to assess left atrial contractile function in disturbed circulatory conditions, it is necessary to have a clear understanding of how it behaves in a normal resting state with changes in loading conditions.
Peter Gottfridsson, Roman A’Roch, Per Lindqvist, Lucy Law, Tomi Myberg, Magnus Hultin, Alexander A’Roch, Michael Haney   +7 more
doaj   +1 more source

Duration of heart failure and the risk of atrial fibrillation: different mechanisms at different times? [PDF]

, 2009
Chronic heart failure increases the risk of atrial fibrillation (AF), with the prevalence of AF paralleling the severity of heart failure.1 Factors that underlie this increased susceptibility to AF may include electrical, structural, and neurohumoral ...
Rankin, A.C., Workman, A.J.
core   +1 more source

Proteogenomic Profiling of Idiopathic Pulmonary Arterial Hypertension Identifies Sex‐Differential Proteins and Candidate Therapeutic Targets

Advanced Science, EarlyView.
An integrated proteogenomic analysis of 44,137 predominantly European‐ancestry UK Biobank participants aged 40–69 years identifies 12 robust proteins associated with idiopathic pulmonary arterial hypertension. These proteins define a high‐mortality molecular endotype, support early detection and mortality prediction, reveal sex‐differential proteomic ...
Xinjie Lin, Yangchang Zhang, Yang Pu, Duanke Liu, Tao Lei, Kai Ma, Qiyu He, Zheng Dou, Yuze Liu, Dengyuan Liu, Yinge He, Yanshang Wang, Xiaojiao Zheng, Yanbing Ma, Jianrong Zhou, Weiding Zhai, Binbin Su, Li Chen, Shoujun Li   +18 more
wiley   +1 more source

Transthoracic Echocardiography as a Tool for Early Detection of Atrial Fibrillation in Patients Receiving Ibrutinib

Life
Background: Bruton’s tyrosine kinase inhibitors, particularly ibrutinib, have improved outcomes in patients with chronic lymphocytic leukemia but are associated with an increased risk of atrial fibrillation.
Vittoria Gammaldi, Martina Pucci, Francesca La Rocca, Pasquale Megaro, Daniele Paoletta, Mariateresa Pontoriero, Luca Maria Capece, Roberto Luise, Marina Iacono, Roberta Esposito   +9 more
doaj   +1 more source

Thickness‐Gradient Liquid Metal Connectors for Seamless Electrophysiological Sensors

Advanced Science, EarlyView.
Thickness‐gradient liquid metal interfaces with elastomeric substrates enable seamless integration between ultrathin skin‐conformal electrodes and external interconnects. The mechanically compliant connector reduces interfacial mismatch and supports stable ECG/EMG monitoring under bending and motion.
Jinyoung Kim, Jaejun Lee, Christopher E. Tabor, Vladimir V. Tsukruk   +3 more
wiley   +1 more source

The Deubiquitinase UCHL1 Drives Susceptibility to Atrial Fibrillation by Stabilizing CaMKII‐δ

Advanced Science, EarlyView.
UCHL1 is highly upregulated in mice and patients with AF. UCHL1 directly binds to and removes K48‐linked polyubiquitin chains from CaMKII‐δ at K251 and enhances CaMKII‐δ stability, which activates RyR2, disrupts Ca2+ handling, and promotes AF. These findings establish UCHL1 as a critical regulator of CaMKII‐δ stability and AF‐related Ca2+ handling ...
Hai‐Lian Bi, Yu‐Hui Gu, Kai‐Wen Ren, Xiao‐Hong Yu, Yun‐Long Xia, Xiao‐Lei Yang, Hui‐Hua Li   +6 more
wiley   +1 more source

Left atrial longitudinal strain/strain rate curves obtained from an apical four-chamber view.

, 2013
εs: peak atrial longitudinal strain during ventricular systole, εa: atrial strain at the onset of P-wave on electrocardiography, SRs: peak left atrial strain during LV systole, SRe: peak left atrial strain during early LV diastole, SRa: peak left atrial ...
Bin Sun (210373), Wen Zhu (149702), Qing Zhou (52712), Guoqian Huang (295892), Ping Yan (145638), Hui Zhu (87035), Haiming Shi (209360), Yuwen Jiang (295890)   +7 more
core   +1 more source

Role of the liver in splanchnic extraction of atrial natriuretic factor in the rat [PDF]

, 1992
Mesenteric, hepatic and splanchnic extraction of C-terminal and N-terminal atrial natriuretic factor was investigated in male Sprague-Dawley rats. Plasma concentrations (mean ± S.E.M.) of C-terminal atrial natriuretic factor were 55.0 ± 6.1 fmol/ml, 31.2
Dieter Jungst, Witthaut, Rochus, Thibault, Gaétan, Manfred Bilzer, Alexander L. Gerbes, Jüngst, Dieter, Gülberg, Veit, Bilzer, Manfred, Gerbes, Alexander L., L Veit Gulberg, Rochus Witthaut, Gaétan Thibault, Veit Gülberg   +12 more
core   +1 more source

A Spatiotemporal Single‐Cell Atlas Uncovers Dysregulated ECM Dynamics and Septal Remodeling Arrest in Human Ventricular Septal Defects

Advanced Science, EarlyView.
Integrating single‐cell and spatial transcriptomics reveals human ventricular septal defect (VSD) as a disease of microenvironmental insufficiency and structural remodeling arrest. Attenuated endothelial‐fibroblast crosstalk, alongside downregulated THBS1/TGF‐β1 and MMP2 signaling networks, impairs the endothelial‐to‐mesenchymal transition (EndoMT) and
Xiaoyuan Zhang, Lun Zhu, Ze Sun, Ruolin Jia, Ziming Wang, Jiayao Zhao, Bohao Liu, Haiqing Xiong, Xiaowei Yu, Yanzhu Yue   +9 more
wiley   +1 more source

Comprehensive Assessment of Left Atrial Function: The Emerging Role of Cardiac Magnetic Resonance Feature Tracking

Journal of Cardiovascular Development and Disease
Traditional volumetric parameters fall short of capturing the complex, phasic nature of atrial function. In contrast, atrial strain has become recognized as a sensitive, non-invasive imaging marker that enables earlier detection of myocardial dysfunction,
Javier Solsona-Caravaca, Alessandro Giustiniani, Eduard Ródenas-Alesina, Laura Galian-Gay, Ruperto Oliveró, Filipa Valente, Guillem Casas, Gisela Teixidó-Turà, Nuria Vallejo, Rubén Fernández-Galera, Víctor González-Fernández, Pablo Escribano-Escribano, Axel Hernández-Pineda, Ignacio Ferreira-González, José Fernando Rodríguez-Palomares   +14 more
doaj   +1 more source