Results 61 to 70 of about 1,852,602 (200)

Systematic Analysis of Gene Expression Differences between Left and Right Atria in Different Mouse Strains and in Human Atrial Tissue [PDF]

, 2011
Background: Normal development of the atria requires left-right differentiation during embryonic development. Reduced expression of Pitx2c (paired-like homeodomain transcription factor 2, isoform c), a key regulator of left-right asymmetry, has recently ...
Fabritz Larissa, Brown Nigel A., Hoffmeier Andreas, Hans Schöler, Piccini, Ilaria, Brown, NA, Scheld, Hans H, Greber, B, Kahr, Peter C, Piccini Ilaria, Boris Greber, Greber Boris, Schöler, H, Hans H. Scheld, Ilaria Piccini, Nigel A Brown, Kahr Peter C., Kahr, PC, Fabritz, Larissa; id_orcid, Hans H Scheld, Piccini, I, Schöler Hans, Kirchhof Paulus, Peter C. Kahr, Brown, Nigel A, Scheld, HH, Kirchhof, P, Fabritz, L, Kirchhof, Paulus; id_orcid, Paulus Kirchhof, Schöler, Hans, Scheld Hans H., Greber, Boris, Hoffmeier, A, Peter C Kahr, Larissa Fabritz, Nigel A. Brown, Andreas Hoffmeier, Hoffmeier, Andreas   +38 more
core   +1 more source

Early dysregulation of cardiac-specific microRNA-208a is linked to maladaptive cardiac remodelling in diabetic myocardium

Cardiovascular Diabetology, 2019
Background The diabetic heart undergoes remodelling contributing to an increased incidence of heart failure in individuals with diabetes at a later stage. The molecular regulators that drive this process in the diabetic heart are still unknown.
Shruti Rawal, Prashanth Thevakar Nagesh, Sean Coffey, Isabelle Van Hout, Ivor F. Galvin, Richard W. Bunton, Philip Davis, Michael J. A. Williams, Rajesh Katare   +8 more
doaj   +1 more source

Percutaneous Left Atrial Appendage Closure Using a PFO Occluder After an Incomplete Surgical Ligation

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT The case regards a 73‐year‐old male who was referred for consideration of percutaneous left atrial appendage closure. His left atrial appendage was ligated during prior mitral valve surgery, but was noted to be patent on a recent transesophageal echocardiography. An Amulet device was selected based on CT planning.
Zach Rozenbaum, Eric Gnall
wiley   +1 more source

In Silico Clinical Trials in Drug Development: Virtual Patients, Applications, and Regulatory Convergence

Clinical Pharmacology &Therapeutics, EarlyView.
Conventional clinical trials remain the benchmark for evaluating therapeutic safety and efficacy, yet they are constrained by escalating costs, withdrawal over the extended follow‐up periods, recruitment difficulties, ethical limits, and a restricted ability to characterize heterogeneous populations.
Maximilian Balmus, Sheng‐Ya Wang, Edward W. G. Ashton, Rosie K. Barrows, Molly Monks, Yuzhang Ge, Arthur Lefebvre, Steven A. Niederer   +7 more
wiley   +1 more source

Intravenous magnesium sulphate and sotalol for prevention of atrial fibrillation after coronary artery bypass surgery: a systematic review and economic evaluation

, 2008
Objectives: To assess the clinical and cost-effectiveness of magnesium sulphate compared with sotalol, and to assess the clinical effectiveness of magnesium sulphate compared with placebo in the prevention of atrial fibrillation (AF) in patients who have
Price, A., J Shepherd, A Price, G Frampton, J Jones, Turner, D., Ł Tanajewski, Frampton, Geoff, Frampton, G., D Turner, Jones, J., Price, A.M., Tanajewski, L., Sheperd, J., Shepherd, J.   +14 more
core   +1 more source

Managing atrial fibrillation in the global community: The European perspective. [PDF]

, 2013
Atrial fibrillation is a common, global problem, with great personal, economic and social burdens. As populations age it increases in prevalence and becomes another condition that requires careful chronic management to ensure its effects are minimised ...
Kaba, RA, Camm, AJ, Williams, TM, Sharma, R   +3 more
core   +1 more source

Transthyretin amyloid cardiomyopathy: Literature review and red‐flag symptom clusters for each cardiology specialty

ESC Heart Failure, Volume 12, Issue 2, Page 955-967, April 2025.
Abstract Wild‐type transthyretin amyloid cardiomyopathy (ATTRwt‐CM) is a progressive and infiltrative cardiac disorder that may cause fatal consequences if left untreated. The estimated survival time from diagnosis is approximately 3–6 years. Because of the non‐specificity of initial symptom manifestation and insufficient awareness among treating ...
Yasuhiro Izumiya, Toru Kubo, Jin Endo, Seiji Takashio, Masatoshi Minamisawa, Jun Hamada, Tomonori Ishii, Hajime Abe, Hiroaki Konishi, Kenichi Tsujita   +9 more
wiley   +1 more source

Cardiac adrenergic control and atrial fibrillation [PDF]

, 2010
Atrial fibrillation (AF) is the most common cardiac arrhythmia, and it causes substantial mortality. The autonomic nervous system, and particularly the adrenergic/cholinergic balance, has a profound influence on the occurrence of AF ...
Workman, A.J.
core   +1 more source

Cardiac remodelling in the era of the recommended four pillars heart failure medical therapy

ESC Heart Failure, Volume 12, Issue 2, Page 1029-1044, April 2025.
Abstract Cardiac remodelling is a key determinant of worse cardiovascular outcome in patients with heart failure (HF) and reduced ejection fraction (HFrEF). It affects both the left ventricle (LV) structure and function as well as the left atrium (LA) and the right ventricle (RV).
Giada Colombo, Tor Biering‐Sorensen, Joao P. Ferreira, Carlo Mario Lombardi, Andrea Bonelli, Andrea Garascia, Marco Metra, Riccardo M. Inciardi   +7 more
wiley   +1 more source

The effects of sodium–glucose cotransporter 2 inhibitors on the ‘forgotten’ right ventricle

ESC Heart Failure, Volume 12, Issue 2, Page 1045-1058, April 2025.
Abstract With the progress in diagnosis, treatment and imaging techniques, there is a growing recognition that impaired right ventricular (RV) function profoundly affects the prognosis of patients with heart failure (HF), irrespective of their left ventricular ejection fraction (LVEF).
Liangzhen Qu, Xueting Duan, Han Chen
wiley   +1 more source