Results 91 to 100 of about 23,182 (204)

Caenorhabditis elegans as an in vivo model system for human inherited primary arrhythmia syndromes

The Journal of Physiology, EarlyView.
Abstract figure legend Most genes involved in inherited primary arrhythmia syndromes (IPAS) are conserved in Caenorhabditis elegans, where genetic manipulation enables functional characterization of variants, identification of regulatory proteins, and in vivo drug testing.
Antoine Delinière, Thomas Boulin, Maëlle Jospin, Alexandre Janin, Gilles Millat, Philippe Chevalier, Olga Andrini   +6 more
wiley   +1 more source

Electrocardiogram Abnormality Classification From Summary Statistics With Patient‐Level Validation and Process‐Focused Evaluation

Annals of Noninvasive Electrocardiology, Volume 31, Issue 5, September 2026.
Patient‐level validation in ECG abnormality classification demonstrates that detailed evaluation (including monotonic decline patterns, learning convergence, and precision‐recall calibration across partitions) is vital for clinical deployment. Aggregate accuracy metrics alone mask critical generalization instabilities, highlighting the need for process‐
Sungjoon Hong, Christina Hartnett, Michael Ruane, Jason Tagliarino, Michael Nizich, M. Toma   +5 more
wiley   +1 more source

Cerebrovascular Events in Aortic Stenosis: From Native Valve Disease to TAVR‐Specific Risk and Prevention

Catheterization and Cardiovascular Interventions, Volume 108, Issue 2, Page 331-342, August 1, 2026.
ABSTRACT Aortic stenosis (AS) is associated with a heightened burden of cardiovascular comorbidities, atrial fibrillation (AF), and progressive valvular calcification, all of which may contribute to cerebrovascular events across the disease continuum.
Priyanka Boettger, Jamschid Sedighi, Martin Juenemann, Omar Alhaj‐Omar, Kerstin Piayda, Mani Arsalan, Samuel Sossalla, Won‐Keun Kim   +7 more
wiley   +1 more source

Unveiling New Insights: Reinterpreting DES Mutation, p.Arg383His, Through a Study of an Iranian Family With Isolated Hypertrophic Cardiomyopathy, Implication for Phenotype–Genotype Correlation Analysis

Clinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT Desmin, a crucial intermediate filament in muscle cells, maintains structural integrity in cardiac muscle and provides stability to striated muscle cells. Mutations in the DES gene lead to desminopathies, causing diverse cardiac and skeletal myopathies.
Saeideh Kavousi, Farzad Kamali, Bahareh Rabbani, Mehrdad Behmanesh, Nejat Mahdieh, Mehrdad Noruzinia   +5 more
wiley   +1 more source

A Challenging Case of Advanced Cardiac Sarcoidosis Refractory to Infliximab Therapy

Clinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT Cardiac sarcoidosis can be life‐threatening, and lack of response to immunosuppressive therapy remains a significant challenge in active disease. We present a case of refractory cardiac sarcoidosis despite third‐line immunosuppression (infliximab). Ongoing multimodality assessment is essential for managing refractory cardiac sarcoidosis.
Manal Ibrahim, Mansimran Singh Dulay, Kshama Wechalekar, Vasileios Kouranos, Rakesh Sharma   +4 more
wiley   +1 more source

A Closed‐Loop Cardiovascular Model of the Supine‐To‐Stand Manoeuvre: Implications for Falls

International Journal for Numerical Methods in Biomedical Engineering, Volume 42, Issue 8, August 2026.
Continuous beat‐to‐beat modeling of supine‐to‐stand hemodynamics in older adults reproduces orthostatic responses and reveals differences in baroreflex, muscle‐pressure, and blood volume in those with a fall history, providing a basis for mechanistic phenotyping to enhance orthostatic hypotension diagnosis.
Joeri A. van de Sande, Valeria Krzhizhanovskaya, Lex M. van Loon, Nathalie van der Velde, Eveline P. van Poelgeest, Marjolein Klop, Jurgen A. H. R. Claassen, Alfons G. Hoekstra   +7 more
wiley   +1 more source

The Human Atrioventricular Node: Oedipus and the Riddle of the Sphinx

Arrhythmia & Electrophysiology Review, 2020
Demosthenes G Katritsis
doaj   +1 more source

A Mechanistic Review of Environmental Stressor to Decode Their Effect on Congenital Malformations: A Developmental Toxicity

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
Environmental toxicants may disrupt developmental pathways via strong molecular docking interactions with hub FGF proteins (FGF9 and FGF4) like dibenzo‐p‐dioxin (−7.2 kcal/mol) at the ASN146 residue of FGF9, driving congenital malformations as revealed by PPI networks and toxicity profiling.
Adarsh Kumar Shukla, Rashmi Mahajan, Anuj Kumar Tyagi, Kamendra Swaroop   +3 more
wiley   +1 more source

A surgical resection case of myxoma arising from the posterior wall of the left atrium complicated with complete atrioventricular block

Journal of Cardiothoracic Surgery
An 80-year-old female was referred to our institution due to transient right upper limb weakness. Transthoracic and transesophageal echocardiography revealed a tumor in the left atrium. The tumor was attached to the posterior wall of the left atrium near
Satoshi Sakakibara, Takashi Yamauchi, Takahiro Ohmori   +2 more
doaj   +1 more source

Atrial High‐Rate Episodes Mirror Atrial Fibrillation in Stroke Prediction: Evidence From an Indian Prospective Cohort

Journal of Arrhythmia, Volume 42, Issue 4, August 2026.
This prospective matched cohort study, which generates hypotheses, finds that device‐detected AF lasting under 24 h is linked to a notably increased risk of stroke/TIA and progression to clinical AF among Indian patients. ABSTRACT Aims To assess the risk of stroke/TIA and progression to atrial fibrillation (AF) in Indian patients with device‐detected ...
Sedhupathi Shanmugam, Sreevilasam P. Abhilash, Jyothi Vijay, Sapna erat Sreedharan, Narayanan Namboodiri   +4 more
wiley   +1 more source