Results 61 to 70 of about 210,193 (269)

Establishing an Antimicrobial Stewardship Collaborative Across a Large, Diverse Health Care System

, 2019
Background: Alarming trends in antibiotic resistance sparked a National Action Plan endorsing antimicrobial stewardship programs (ASPs) in health care facilities. Atrium Health consists of 28 acute care facilities with varying levels of ASP maturity. The
Logan, Andrea Y., Jarrett, Steven W., Boger, Michael S., Williamson, Julie E., Davidson, Lisa E., Reinke, Emily K.   +5 more
core   +1 more source

Bioinspired Passive Flow Routing to Mitigate Thrombosis in Prosthetic Heart Valves and Cardiovascular Devices

Advanced Science, EarlyView.
Bioinspired passive flow routing mitigates thrombosis in cardiovascular devices by redirecting a small fraction of forward flow into stagnation‐prone regions. Inspired by avian alula and aircraft slat mechanisms, strategically placed routing channels restore washout around mechanical heart valves, reducing low‐shear exposure by four orders of magnitude
Yevgeniy Kreinin, Mark Epshtein, Yahel Talmon, Tirosh Mekler, Itay Or, Mahli Raad, Gil Bolotin, Josué Sznitman, Netanel Korin   +8 more
wiley   +1 more source

Changes in pain and prosthesis wear following transfemoral osseointegration combined with sciatic nerve RPNI

OTA International
. Background:. Osseointegration (OI) has revolutionized prosthetic rehabilitation for amputees. Despite its contributions, postamputation pain remains a significant problem. This study aims to investigate the role of sciatic nerve regenerative peripheral
Kirby W. Bonvillain, II, MD, Ainsley K. Bloomer, MD, G. Dillon Graham, MD, Ryan P. Serbin, MD, Rachel B. Seymour, PhD, Joseph R. Hsu, MD, Bryan Loeffler, MD   +6 more
doaj   +1 more source

Bioengineered Exosome‐Loaded Immunomodulatory Bioadhesive Spray Reverses Liver Fibrosis and Metabolic Dysfunction That Triggers Beneficial Gut‐Liver Crosstalk in Chronic Fatty Liver Disease

Advanced Science, EarlyView.
Umbilical cord stem cell‐derived exosomes encapsulated in an immunomodulatory bioadhesive hydrogel spray enable localized therapy, sustained vesicle delivery, macrophage polarization, suppress systemic inflammation, and mitigate glucose and insulin homeostasis impairments in MAFLD.
Triya Saha, Ayushi Mairal, Shreya Mehrotra, Shiv K. Sarin, Ashok Kumar   +4 more
wiley   +1 more source

Introducing Borsantrazole: A Trifunctional Boron‐Based Pyrazole That Extends the Lifespan of Amyotrophic Lateral Sclerosis Mice

Advanced Science, EarlyView.
Herein we report a boron‐based pyrazole, (Borsantrazole ‐ a small molecule that selectively targets oxidative stress) that significantly increases survival, reduces weight loss, delays disease onset, and affects global protein changes in the SOD1‐G37R mouse model of ALS.
Nitesh Sanghai, Rhonda Kelley, Ying Lao, M. Immanuel Reyes Madlangsakay, Prasanta Paul, M. Alejandra Llanes‐Cuesta, Jun‐Feng Wang, René P. Zahedi, Jiming Kong, Geoffrey K. Tranmer   +9 more
wiley   +1 more source

Label‐Free Myelin Fingerprinting: An Adult Human Post‐Mortem Brain Slice Platform via Coherent Anti‐Stokes Raman Spectroscopy

Advanced Science, EarlyView.
A serum‐free, air–liquid interface organotypic slice culture model preserves human post‐mortem corpus callosum tissue, successfully recovering from slicing trauma to reflect the donor's underlying disease state. Pairing label‐free Coherent anti‐Stokes Raman scattering (CARS) microscopy with k‐means clustering enables objective, high‐resolution ...
Kasra Roya‐Kouchaki, Jeroen P. Korterik, Femke Tjebbes, Geert J. Schenk, Herman L. Offerhaus, Antonio Luchicchi   +5 more
wiley   +1 more source

Not a magic pill: a qualitative exploration of provider perspectives on antibiotic prescribing in the outpatient setting

BMC Family Practice, 2018
Background Inappropriate prescribing of antibiotics poses an urgent public health threat. Limited research has examined factors associated with antibiotic prescribing practices in outpatient settings.
Traci D. Yates, Marion E. Davis, Yhenneko J. Taylor, Lisa Davidson, Crystal D. Connor, Katherine Buehler, Melanie D. Spencer   +6 more
doaj   +1 more source

ATRIUM Peer Review Framework (Version 1)

The ATRIUM project (Advancing FronTier Research In the Arts and hUManities) aims to strengthen and integrate research infrastructure services across the arts and humanities.
Gouzi, Françoise, Bénière, Sarah, Delmazo, Carol, Tasovac, Toma, Baillot, Anne, Garnett, Victoria   +5 more
core   +1 more source

Intermittent Fasting Restores Cardiac Lipid Homeostasis in Diabetic Cardiomyopathy in Association With Akkermansia Muciniphila and 1‐methyl‐L‐histidine

Advanced Science, EarlyView.
Intermittent fasting reshapes the gut microbiota in diabetic cardiomyopathy, restoring Akkermansia muciniphila and the microbiota‐associated metabolite 1‐methyl‐L‐histidine. This shift is linked to improved cardiac lipid homeostasis, reduced lipid peroxidation, and attenuated myocardial injury, highlighting a gut microbiota–metabolite–lipid axis in ...
Kaiyuan Jiang, Fen Xiong, Yiwen Peng, Lingfei Meng, Xinran Wang, Yingruo Xu, Tian Tang, Hongchang Gao   +7 more
wiley   +1 more source

Atrial Arrhythmias and Electroanatomical Remodeling in Patients With Left Ventricular Assist Devices

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
Background The incidence, predictors, and impact of atrial arrhythmias along with left atrial structural changes in patients with left ventricular assist devices (LVADs) remain undetermined.
Amrish Deshmukh, Gene Kim, Martin Burke, Emeka Anyanwu, Valluvan Jeevanandam, Nir Uriel, Roderick Tung, Cevher Ozcan   +7 more
doaj   +1 more source