Integrative Omics Defines Metabolic Biomarkers and Genetic Regulatory Mechanisms of Mortality Risk
Understanding mortality mechanisms remains a fundamental challenge. Through multi‐omics analysis of a three‐generation chicken model, are identified 45,585 mQTLs and establish a 16‐metabolite predictor of mortality. An inflammation‐growth trade‐off and evolutionarily conserved pathways involving butyrate–microbiota interactions and L‐cysteine's dual ...
Peihao Liu +10 more
wiley +1 more source
Case report of an aggressive cardiac myxofibrosarcoma with rapid disease progression. [PDF]
Nakamura K +4 more
europepmc +1 more source
Mitochondrial Adaptation to Mechanical Stress in Cardiac Ageing and Disease
Mechanical forces shape the heart's energy factories. This review explores how mitochondria in cardiac cells sense and respond to biomechanical stress, altering their structure, positioning, and metabolism. By linking mechanical cues to mitochondrial adaptation, the article highlights pathways driving heart disease and points to new strategies for ...
Aishwarya Prakash, Thomas Iskratsch
wiley +1 more source
Quadricuspid Right Atrioventricular Valve: A Cadaveric Case Report. [PDF]
Buckway T, Weed M, Tobon A, Reynolds A.
europepmc +1 more source
A flexible piezoresistive sensor with a 3D tri‐scale graded microstructure is proposed, overcoming the trade‐off between sensitivity and linearity. The device achieves ultra‐high sensitivity (138.6 kPa−1), a broad linear range (400 kPa, R2 = 0.99), and exceptional stability (24 000 repeated loading cycles), enabling precise detection of physiological ...
Rui Chen +6 more
wiley +1 more source
A sensor-fused BIM-based ıntelligent control system for energy-efficient ındoor environmental regulation using deep actor-critic reinforcement learning (DACRL). [PDF]
Tong L.
europepmc +1 more source
Primate Swallowing Is Powered by Both Rotation and Contraction of Suprahyoid Muscles
ABSTRACT Objectives Swallowing biomechanics in primates and other mammals is poorly understood, and the effect of hyoid descent on swallowing biomechanics lacks experimental interrogation. In macaques, which share similar swallowing kinematics with humans, the base of the tongue and the food bolus are hypothesized to be driven into the oropharynx by a ...
Courtney P. Orsbon +2 more
wiley +1 more source
An explainable machine learning framework for multi-objective carbon reduction targeting material operational seasonal emissions in building retrofits. [PDF]
Zhu H +5 more
europepmc +1 more source
Abstract INTRODUCTION Alzheimer's disease (AD) is a progressive neurodegenerative disorder with limited treatments and poorly defined environmental risks. Micro‐ and nanoplastics (MNPs) are widespread pollutants linked to neurotoxicity, but their role in AD remains unclear.
Yizhou Zhong +20 more
wiley +1 more source
ScienCrown Valve: A Novel Transcatheter Heart Valve for Concurrent Aortic and Mitral Valve-in-Valve Implantation in Bioprosthetic Degeneration. [PDF]
Ding JD +5 more
europepmc +1 more source

