Results 71 to 80 of about 1,287,047 (358)
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Failure of attachment strategies and the adaptive value of desperation: Cabo’s choice.
, 2008 The exposure to maltreatment and to conditions of danger during childhood and adulthood is very common among humans. In serious conditions of danger, when attachment strategies fail, adaptive defensive reactions can manifest themselves: the alternation ...
BALDONI, FRANCO
core
An exploratory study on the links between individual upcycling, product attachment and product longevity [PDF]
, 2015 Product attachment, the emotional bond experienced with a product, is an emerging concept for sustainable production and consumption. The logic behind it is that when people are attached to any product, they are more likely to handle the product with ...
Kettley, Sarah +7 more
core +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
The Measurement of Place Attachment: Validity and Generalizability of a Psychometric Approach
Forestry sciences, 2003 To enhance land managers' ability to address deeper landscape meanings and place-specific symbolic values in natural resource decision making, this study evaluated the psychometric properties of a place attachment measure designed to capture the extent
Daniel R. Williams, J. Vaske
semanticscholar +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
The emergence of the disorganised/disoriented (D) attachment classification, 1979-1982
, 2015 This article examines the emergence of the concept of infant disorganized/disoriented attachment, drawing on published and archival texts and interviews.
Duschinsky, Robbie
core +1 more source
Frontiers in Microbiology, 2017 Campylobacter jejuni is a major foodborne pathogen that causes severe gastroenteritis in humans characterized by fever, diarrhea, and abdominal cramps. In the human gut, Campylobacter adheres and invades the intestinal epithelium followed by cytolethal ...
Dan J. Donoghue +6 more
doaj +1 more source