Results 101 to 110 of about 19,388,770 (317)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Maternal attachment styles and maternal-fetal attachment: The serial mediation role of alexithymia and depressive symptoms

Fides et Ratio
Maternal-fetal attachment refers to the emotional and cognitive bond a pregnant woman develops with her unborn child. This bond plays a significant role in prenatal care behaviors and the later formation of the mother-infant relationship.
Piotr Nowicki
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Relationship between metacognitive skills and career exploration outcome expectations: mediating role of parental and peer attachment styles

BMC Psychology
Background Early career development—the first stage of an individual’s journey to get to know themselves and their profession—is very important in the career choice process.
Serkan Volkan Sari, Fatih Camadan, Sefa Özmen   +2 more
doaj   +1 more source

A qualitative investigation of revitalisation efforts to foster residents’ attachment in dilapidated neighbourhoods: Is identity a matter?

Journal of Urban Management
Historic neighborhoods in the Global South face challenges like urban core shrinkage and gentrification, impacting residents' socio-cultural dynamics. This qualitative study aims to identify critical aspects contributing to the deterioration of historic ...
Mohammad Javad Maghsoodi Tilaki, Sharareh Farhad   +1 more
doaj   +1 more source

Maternal and peer attachment, identity formation, and non-suicidal self-injury: a longitudinal mediation study

Child and Adolescent Psychiatry and Mental Health, 2019
Background Non-suicidal self-injury (NSSI) is defined as the repetitive, direct, and deliberate destruction of one’s body tissue without an intention to die.
Amarendra Gandhi, Koen Luyckx, Geert Molenberghs, Imke Baetens, Lien Goossens, Shubhada Maitra, Laurence Claes   +6 more
doaj   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

THE DWELLERS’ ATTACHMENT TO JOGLO HOUSES IN KOTAGEDE

Dimensi: Journal of Architecture and Built Environment, 2020
The number of Joglo houses in existence has decreased in recent years. Any effort to conserve the remaining Joglo depends on the behavior of the dwellers in maintaining and utilizing Joglo properly.
Deny Prastika Candra, Wara Indira Rukmi, Deni Agus Setyono   +2 more
doaj   +1 more source