Results 51 to 60 of about 73,146 (264)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Pengaruh Kelekatan Terhadap Ekspresi Emosi dalam Relasi Pernikahan

Psikologika: Jurnal Pemikiran dan Penelitian Psikologi, 2015
The purpose of this research is to explore: 1) the correlation between attachment style and emotional expression in a marital relationship, 2) the correlation between secure attachment style and positive emotional expression in a marital relationship, 3)
Rena Latifa
doaj  

Sex differences in attachment styles

Current Opinion in Psychology, 2019
Sex differences in attachment styles have been found in adulthood, emerge as early as middle childhood, and can be sizable when described at the appropriate level of analysis. However, they have received relatively little attention in mainstream attachment research.
openaire   +3 more sources

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

The effect of parenting style on aggressive behavior in adolescents: the chain mediating roles of self-control and attachment

Frontiers in Psychiatry
IntroductionWe investigated the mediating effects of self-control and attachment in the relationship between parenting style and aggressive behavior among Chinese adolescents.MethodsA total of 617 adolescents from Jiangsu, Henan and Hunan provinces ...
Jin Xie, Ying Zou, Yang Peng, Can Zhou, Qingtao Dong, Zhendong Yao   +5 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Predicting High School Teachers’ Emotional Intelligence Based on their Attachment Styles [PDF]

خانواده و پژوهش, 2018
The purpose of the present study was to predict high school teachers’ emotional intelligence based on their attachment styles (Close, Depend, and Anxiety Dimensions).
A.A. Haddadi Kuhsar, Ph.D., J. Hassani, Ph.D.   +1 more
doaj  

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Measure of Attachment Style

International Journal of Indian Psychology, 2016
This paper describes the development and standardization of a measure of perceived attachment styles. The four attachment styles namely secure, avoidant insecure, ambivalent insecure, and disorganized insecure attachment proposed by Mary Ainsworth (1970), Main and Soloman 1986 (Disorganized- insecure attachment).
null Nasheed Imtiaz, null Azmat Jahan, null Naseem Ahmad   +2 more
openaire   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source