‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
FEBS Letters, EarlyView.Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
An Efficient DDoS TCP Flood Attack Detection and Prevention System in a Cloud Environment [PDF]
, 2017 Although the number of cloud projects has dramatically increased over the last few years, ensuring the availability and security of project data, services, and resources is still a crucial and challenging research issue.
Sahi, Aqeel +7 more
core +1 more source
Attack simulation and signature extraction of low-rate DDoS
Tongxin xuebao, 2008 LDDoS （low-rate distributed denial-of-service） was a new type of DDoS attack. It had small traffic and cov- ered by normal network traffic. LDDoS attack was so stealthy that the detection and defense approaches of traditional DDoS could not be effective.
WU Zhi-jun, ZHANG Dong
doaj +2 more sources
An Shilling Attack Detection Algorithm Based on Item Popularity and Novelty Degree Features
工程科学与技术, 2017 :The existing supervised detection algorithms have low precision when they detect shilling attacks.To address this problem,a shilling attack detection algorithm based on the features of popularity and novelty degree was proposed.Firstly,according to the ...
于洪涛, 周倩楠, 张付志
doaj
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
1. 08102 Executive Summary – Perspectives Workshop: Network Attack Detection and Defense
, 2008 From March 2nd to 6th, 2008, the Dagstuhl Perspective Workshop 08102 Net-work Attack Detection and Defense was held at the International Conference and Research Center (IBFI), Schloss Dagstuhl.
Carle, Georg +4 more
core +1 more source
An Analysis of GPS Spoofing Attack and Efficient Approach to Spoofing Detection in PX4
IEEE AccessUnmanned Aerial Vehicles (UAVs) are aerial vehicles that can go to a particular position without human control or with remote human control. It is because unmanned control mainly relies on position estimation that a lot of research has been studied on ...
Ji Hyuk Jung +3 more
doaj +1 more source
Intrusion Detection of NSM Based DoS Attacks Using Data Mining in Smart Grid
Energies, 2012 In this paper, we analyze the Network and System Management (NSM) requirements and NSM data objects for the intrusion detection of power systems; NSM is an IEC 62351-7 standard.
JungChan Na +5 more
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source