Results 41 to 50 of about 138,649 (299)

Climate analogues suggest limited potential for intensification of production on current croplands under climate change

Nature Communications, 2016
Simulations of the impact of future climate change on crop yield vary considerably. Here, the authors use a climate analogue approach to estimate the response of maximum attainable yield to climate change and predict that large shifts in land use and ...
T.A.M. Pugh, C. Müller, J. Elliott, D. Deryng, C. Folberth, S. Olin, E. Schmid, A. Arneth   +7 more
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Optimizing agronomic practices for closing rapeseed yield gaps under intensive cropping systems in China

Journal of Integrative Agriculture, 2020
A yield gap analysis for rapeseed (Brassica napus L.) is critical to meeting the oil demand by identifying yield potential and yield constraints. In this study, potential yield (Yp), attainable yield (Yatt), and actual yield (Yact) for winter rapeseed ...
Zhi ZHANG, Ri-huan CONG, Tao REN, Hui LI, Yun ZHU, Jian-wei LU   +5 more
doaj   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Adapting the QUEFTS model to predict attainable yields when training data are characterized by imperfect management

Field Crops Research, 2021
يعد فهم استجابات الغلة لتطبيق المغذيات أحد المدخلات الرئيسية للمشورة الإرشادية والاستثمارات الزراعية الاستراتيجية في البلدان النامية. نموذج شائع الاستخدام لاستجابات الغلة لمدخلات المغذيات في أنظمة زراعة أصحاب الحيازات الصغيرة الاستوائية هو QUEFTS (التقييم الكمي لخصوبة التربة الاستوائية).
Arie Pieter Paulus Ravensbergen, Jordan Chamberlin, Peter Craufurd, Bello Muhammad Shehu, Renske Hijbeek   +4 more
openaire   +2 more sources

Prognostic Impact of European LeukemiaNet Genetic Risk Stratification System in Adult Patients With Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
This study aimed to evaluate the prognostic value of ELN2017 in predicting survival outcomes and to assess the impact of clinical and molecular factors such as age, FLT3 and NPM1 mutations, and allogeneic hematopoietic stem cell transplantation (allo‐HSCT).
Mobina Shrestha, Bishwas Mandal, Vishal Mandal, Asis Shrestha, Amir Babu Shrestha   +4 more
wiley   +1 more source

Estimating the Yield Gap of Irrigated Wheat)Triticum aestivum L.( in Lorestan Province, Iran, the Modeling Approach [PDF]

بوم شناسی کشاورزی
Introduction Removing the gap between the yield that is currently obtained by farmers and the yield that can be obtained by using the best water, soil, and crop management practices (yield gap) is the key solution to overcoming the nutritional challenge ...
Kourosh Heidari, Mashallah Daneshvar, Sajjad Rahimi-Moghaddam, Aliheidar Nasrollahi   +3 more
doaj   +1 more source

Bioengineering of Canopy Photosynthesis in Rice for Securing Global Food Security: A Critical Review

Agronomy, 2023
The emerging threat of climate change is posing a scientific conundrum for global food and nutritional security. As a primary staple food, half of the global human population is supported by rice crop.
Chandrapal Vishwakarma, Gopinathan Kumar Krishna, Riti Thapar Kapoor, Komal Mathur, Shambhu Krishan Lal, Ravi Prakash Saini, Pranjal Yadava, Viswanathan Chinnusamy   +7 more
doaj   +1 more source

Impact of projected climate change on workability, attainable yield, profitability and farm mechanization in Norwegian spring cereals [PDF]

Soil and Tillage Research, 2019
Abstract In cold-temperate climate with high soil water content in spring, the farmer often faces the choice between topsoil compaction during seedbed preparation and delayed sowing, both of which may reduce attainable cereal yield. The objective of this study was to explore whether future climate change with increasing precipitation would aggravate ...
Kolberg, Dorothée, Riley, Hugh, Persson, Tomas, Mangerud, Kjell   +3 more
openaire   +2 more sources

Impact of APOE ε4 Genotype Load on Cognitive Function and Lipid Metabolism in Patients With Cerebral Small Vessel Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Apolipoprotein ε4 (APOE ε4) is a potent genetic risk factor for Alzheimer's disease (AD). However, its role in cerebral small vessel disease (CSVD) remains unclear. Given the clinical and pathological similarities between CSVD and AD, this study aimed to investigate the associations of APOE ε4 gene dosage with cognitive function and
Tingru Jin, Haocheng Yang, Feng Liu, Sihao Lin, Junru Hu, Jian Wang, Yulan Gou   +6 more
wiley   +1 more source