Results 131 to 140 of about 3,113,380 (249)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Clinical practice guidelines for the assessment and management of attention-deficit/hyperactivity disorder

, 2019
Ruchita Shah, Sandeep Grover, Ajit Avasthi   +2 more
openalex   +1 more source

Obstetric complications in children with Attention Deficit/Hyperactivity Disorder and Learning Disability

, 2020
Mamatha Bhat, Natalie Grizenko, Leila Ben Amor, Ridha Joober   +3 more
openalex   +2 more sources

PDANet: Pyramid Density-aware Attention Net for Accurate Crowd Counting [PDF]

, 2020
Saeed Amirgholipour, Xiangjian He, Wenjing Jia, Dadong Wang, Lei Liu   +4 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Attention affects overall gain but not selective contrast at meter frequencies in the neural processing of rhythm [PDF]

, 2020
Tomas Lenc, Peter E. Keller, Manuel Varlet, Sylvie Nozaradan   +3 more
openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Does the Coronavirus Epidemic Take Advantage of Human Optimism Bias?

Frontiers in Psychology, 2020
Hugo Bottemanne, Hugo Bottemanne, Orphée Morlaàs, Philippe Fossati, Philippe Fossati, Liane Schmidt   +5 more
doaj   +1 more source

Children Sustain Their Attention on Spatial Scenes When Planning to Describe Spatial Relations Multimodally in Speech and Gesture. [PDF]

Dev Sci
Ünal E, Karadöller DZ, Özyürek A.
europepmc   +1 more source

A Self-Attention Model for Inferring Cooperativity between Regulatory Features [PDF]

, 2020
Fahad Ullah, Asa Ben‐Hur
openalex   +1 more source