Molecular Oncology, EarlyView.Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho +11 more
wiley +1 more source
X. The Importance of Individual Treatment with special Attention to the size of the Tumour [PDF]
, 1947 openalex +1 more source
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
Does the Coronavirus Epidemic Take Advantage of Human Optimism Bias?
Frontiers in Psychology, 2020 Hugo Bottemanne +5 more
doaj +1 more source
Fodder scarcity has been a permanent factor in India, which in recent times is becoming inore and more acute with the increase in population and devotion of more attention to money crops like cotton, tobacco, sugarcane etc. According to a recent census in Madras, an area of 7 million acres of cultivated land has passed over from food crops to commercial crops in the Madras Presidency in the present decade (8). As a result of the introduction of money crops and the conversion of grazing lands … [PDF]
, 1948 A MARIAKULANDAΙ
openalex +1 more source
Control of goal-directed and stimulus-driven attention in the brain
Nature Reviews Neuroscience, 2002 M. Corbetta, G. Shulman
semanticscholar +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Molecular Oncology, EarlyView.C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald +18 more
wiley +1 more source
Heart rate defined sustained attention relates to visual attention in autism and fragile X syndrome. [PDF]
Sci RepWall CA +6 more
europepmc +1 more source