Results 201 to 210 of about 3,994,873 (380)

Hydroxyapatite Binding Peptide Lipid Nanoparticles for Biomimetic mRNA Delivery to Bone

open access: yesAdvanced Therapeutics, EarlyView.
Targeted delivery of therapeutic mRNA to peripheral tissues, including bone, is currently challenging. In the current work, a hydroxyapatite binding peptide (HABP) is conjugated to mRNA lipid nanoparticles (LNPs). HABP‐LNPs delivered systemically are demonstrated to reduce transfection in the liver and improve transfection in the femurs of mice ...
Joshua A. Choe   +6 more
wiley   +1 more source

Opportunities in Therapeutic mRNA Stabilization: Sequence, Structure, Adjuvants and Vectors

open access: yesAdvanced Therapeutics, EarlyView.
Current mRNA lipid nanoparticles rely on cold storage, which increases the cost and reduces access to the vaccines. As mRNA expands to other clinical opportunities, better methods to stabilize the medicines during shipping, storage, and delivery are needed.
Joshua A. Choe   +4 more
wiley   +1 more source

When Two Becomes Three: Predicting Stable Ternary Boron‐Based Compounds by Populating Unique Lattice Sites in Binary Prototype Structures

open access: yesAdvanced Theory and Simulations, EarlyView.
By substituting lattice sites in 16 binary prototypes, over 27 000 boron‐based ternary compounds are studied, revealing 155 stable candidates. The analysis identifies 31 compounds with superior hardness and elastic moduli compared to their binary counterparts.
Adam Carlsson   +2 more
wiley   +1 more source

Caregiver Strain in Children with Attention Deficit Hyperactivity Disorder. [PDF]

open access: yesIndian J Psychol Med
Chandrakar A   +4 more
europepmc   +1 more source

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