Results 231 to 240 of about 3,994,873 (380)

Structural Diversity of Mitochondria in the Neuromuscular System across Development Revealed by 3D Electron Microscopy

open access: yesAdvanced Science, EarlyView.
Mitochondria across the entire neuromuscular system have been comprehensively reconstructed at different developmental stages using 3D electron microscopy. Fundamental structural principles related to synaptic function are preserved across development, and these morphologies are adapted to ensure effective neural circuit function.
J. Alexander Bae   +9 more
wiley   +1 more source

SIRT3‐Mediated Deacetylation of DRP1K711 Prevents Mitochondrial Dysfunction in Parkinson's Disease

open access: yesAdvanced Science, EarlyView.
SIRT3‐mediated deacetylation of DRP1 at K711 resists mitochondrial dysfunction and DA neuronal death in PD, uncovering a treatment target. Abstract Dysregulation of mitochondrial dynamics is a key contributor to the pathogenesis of Parkinson's disease (PD).
Ye Xi   +11 more
wiley   +1 more source

Correlation between attention deficit/hyperactivity disorder and chronic pain: a survey of adults in Japan. [PDF]

open access: yesSci Rep
Kasahara S   +7 more
europepmc   +1 more source

Artificial Cornea Substitute Based on Hydrogel Skeletons with Natural Stromal Hierarchical Structure and Extracellular Matrix for Sutureless Transplantation

open access: yesAdvanced Science, EarlyView.
Humanized corneal stroma‐like adhesive patches (HCSPs) are developed for lamellar keratoplasty and corneal perforation repair. HCSPs exhibit histological, optical, and biomechanical characteristics similar to those of the natural cornea, with improved wet tissue adhesion, anti‐degradation, and anti‐swelling capabilities compared to conventional tissue ...
Long Zhao   +9 more
wiley   +1 more source

Impact of the polygenic risk scores for attention-deficit/hyperactivity disorder in Alzheimer's disease. [PDF]

open access: yesAlzheimers Dement
Leffa DT   +25 more
europepmc   +1 more source

Adult attention-deficit hyperactivity disorder: key conceptual issues.

open access: yesLancet psychiatry, 2016
P. Asherson   +3 more
semanticscholar   +1 more source

Targeting Senescence with Apigenin Improves Chemotherapeutic Efficacy and Ameliorates Age‐Related Conditions in Mice

open access: yesAdvanced Science, EarlyView.
As a plant‐derived flavonoid, apigenin directly targets PRDX6 to inhibit its PLA2 activity, blocking HSPA8 activation and disturbing its interactions with ATM and p38MAPK in senescent cells. By dampening wide spectrum expression of the SASP, apigenin prevents loss of tissue homeostasis, improves organ function, and alleviates multiple age‐related ...
Hongwei Zhang   +10 more
wiley   +1 more source

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