Results 241 to 250 of about 4,580,020 (399)

High Specific Strength Eutectic High‐Entropy Alloy: Collaborative Effects of TRIP, TWIP, and Nanoprecipitation

open access: yesAdvanced Science, EarlyView.
This study has designed a novel CoCrNiAl eutectic high‐entropy alloy with a two‐level heterogeneous structure with extremely high strength. The high mechanical properties originate from the collaborative strengthening mechanisms, including TWIP, TRIP, and nanoprecipitation.
Z. Q. Wang   +3 more
wiley   +1 more source

Activation of Kir4.1 Channels by 2‐D08 Promotes Myelin Repair in Multiple Sclerosis

open access: yesAdvanced Science, EarlyView.
Multiple sclerosis causes myelin loss and neurological dysfunction. This study shows that 2‐D08, a small molecule targeting Kir4.1 channels, promotes OPCs differentiation via FYN tyrosine kinase phosphorylation and the FYN/MYRF pathway. It significantly improves myelin repair and motor deficits in EAE mice and marmosets, highlighting its potential as a
Mingdong Liu   +17 more
wiley   +1 more source

Executive and attentional contributions to Theory of Mind deficit in attention deficit/hyperactivity disorder (ADHD)

open access: yesChild Neuropsychology: A Journal of Normal and Abnormal Development in Childhood and Adolescence, 2016
A. Mary   +6 more
semanticscholar   +1 more source

Cardiac Slc25a49‐Mediated Energy Reprogramming Governs Doxorubicin‐Induced Cardiomyopathy through the G6P–AP‐1–Sln Axis

open access: yesAdvanced Science, EarlyView.
Doxorubicin‐induced cardiomyopathy involves mitochondrial energy metabolism dysfunction, exacerbated by cardiomyocyte‐specific Slc25a49 deficiency via oxidative phosphorylation (OXPHOS) suppression and glycolysis activation. The Slc25a49–glucose‐6‐phosphate (G6P)–activator protein‐1 (AP‐1) axis drives myocardial injury by upregulating Sln, disrupting ...
Sitong Wan   +16 more
wiley   +1 more source

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