Results 101 to 110 of about 7,179,186 (303)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Intrathalamic Mechanisms of Visual Attention

Journal of Neurophysiology, 2009
The classical model of visual processing emphasizes the lateral geniculate nucleus (LGN) as the major intermediary between the retina and visual cortex. Yet, anatomical findings inspired Francis Crick to suggest an alternative model in which the thalamic reticular nucleus, which envelops the LGN, acts as the “guardian” of visual cortex by modulating ...
openaire   +3 more sources

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Knowledge-Enhanced Dual-Attention Mechanism Recommendation Method

IEEE Access
Knowledge graph (KG), when used as supplementary information in the recommendation domain, effectively alleviate the data sparsity and cold start problems inherent to collaborative filtering.
Lisi Zhang, Beijing Zhou, Wei Cui
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Semantic Modulation of Temporal Attention: Distributed Control and Levels of Abstraction in Computational Modelling [PDF]

, 2006
This paper presents a computational exploration of how meaning modulates temporal attention. This has been explored within the context of Barnard et al's key-distractor Attentional Blink (AB) and proposes a mechanism by which attention is captured by ...
Su, Li, Barnard, Philip, Bowman, Howard
core  

What do Diana monkeys know about the focus of attention of a conspecific? [PDF]

, 2004
Converging experimental and observational evidence suggests that some non-human primates are able to co-orient with shifts in visual attention, both of conspecifics and humans. However, the underlying cognitive mechanisms involved are unclear.
Scerif, G, Gómez, Juan Carlos, Richard W. Byrne, Juan-Carlos Gomez, Byrne, Richard William, Byrne, RW, Gaia Scerif, Gomez, Juan-Carlos, Scerif, Gaia, Byrne, Richard William; id_orcid, Gomez, Juan-Carlos; id_orcid   +10 more
core   +1 more source

Attention Mechanism-Based Cognition-Level Scene Understanding

Information
Given a question–image input, a visual commonsense reasoning (VCR) model predicts an answer with a corresponding rationale, which requires inference abilities based on real-world knowledge.
Xuejiao Tang, Wenbin Zhang
doaj   +1 more source