Results 31 to 40 of about 95,566 (266)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Analysis of air jets velocity attenuation at special initial conditions

Diagnostyka, 2022
The article is devoted to solving the significant problem of efficiency increasing of air distribution in the premise by swirl air jet. The aim of the article is to decrease coefficient of velocity attenuation due to intensification of initial turbulence
Orest Voznyak, Nadiia Spodyniuk, Olena Savchenko, Oleksandr Dovbush, Mariana Kasynets, Oleksandra Datsko   +5 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Representative Elementary Length to Measure Soil Mass Attenuation Coefficient

The Scientific World Journal, 2014
With increasing demand for better yield in agricultural areas, soil physical property representative measurements are more and more essential. Nuclear techniques such as computerized tomography (CT) and gamma-ray attenuation (GAT) have been widely ...
J. A. R. Borges, L. F. Pires, J. C. Costa   +2 more
doaj   +1 more source

Attenuation coefficient for surface acoustic waves in fluid region

Vietnam Journal of Mechanics, 2012
In recent years, surface acoustic wave devices used in bio-sensing applications have demonstrated high sensitivity in the detection of fluid properties such as density, viscosity, stream velocity.
Bui Thu Hang, Bui Duc Tung, Nguyen Tien Dat, Chu Duc Trinh   +3 more
doaj   +1 more source

Light attenuation coefficient of polarization attenuator at high attenuation level

Acta Physica Sinica, 2010
By use of the Jones vector we deduced the Jones matrix of actual polarizer and light transmission expression, as well as the light attenuation coefficient （LAC） of two polarizers. According to computation, certain error exists when using Malus-Law to calculate polarizer’s light attenuation ratio at high attenuation level.
null Huang Chong, null Chen Hai-Qing, null Liao Zhao-Shu, null Zhao Shuang   +3 more
openaire   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Use of Quantitative Ultrasound to Measure Acoustic Properties of Human Skin

Archives of Acoustics, 2014
The scattering of ultrasonic waves depends on the size, shape, acoustical properties and concentration of scatterers in the tissue. The spectrum of the ultrasonic backscatter can be used to characterize non-invasively the structural and ...
Hanna PIOTRZKOWSKA, Jerzy LITNIEWSKI, Marcin LEWANDOWSKI, Elżbieta SZYMAŃSKA, Andrzej NOWICKI   +4 more
doaj  

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source