Mechanosensitive Piezo1/Osteocalcin/Irisin Axis Protects Against Disuse‐Induced Muscle Atrophy
Advanced Science, EarlyView.Mechanical unloading suppresses bone Piezo1 expression, which reduces circulating undercarboxylated osteocalcin (unOCN). unOCN reduction subsequently exacerbates IMM‐induced Fndc5/Irisin decrease and drives severe muscle atrophy. Bone Piezo1 activation or exogenous osteocalcin/Irisin ameliorate muscle atrophy, while muscle‐specific Gprc6a or Fndc5 ...
Zhaolu Wang +5 more
wiley +1 more source
Attitudes, Help-Seeking Barriers, and Predictors of Intention to Use Telemental Health Services Among University Students in Saudi Arabia: A Cross-Sectional Study. [PDF]
Healthcare (Basel)Aldhamri Y.
europepmc +1 more source
Ultra‐Low Intensity Continuous Wave Laser Ablation Propulsion With Graphene‐Engineered Wood
Advanced Science, EarlyView.Graphene delignified wood converts continuous wave laser energy into thrust. Laser propulsion experiments in vacuum reveal the lowest laser ablation threshold intensities and the greatest density‐normalized specific impulse in literature. The results highlight graphene delignified wood as a potential efficient, sustainable, strong, and lightweight ...
Afnan S. M. Elmubasher +10 more
wiley +1 more source
Preschool and primary school teachers' attitudes toward students with type 1 diabetes: A cross-sectional study. [PDF]
PLoS OneMartín-Báez MY, Díaz-González CM.
europepmc +1 more source
Advanced Science, EarlyView.A novel near‐infrared‐II fluorescent imaging capsule endoscope that detects specific fluorescence signals above 900 nm enables highly sensitive, targeted imaging of gastrointestinal cancer tissue. This wirelessly powered and magnetically controlled “smart pill” achieves high sensitivity and deep tissue penetration, allowing precise, non‐invasive ...
Weicheng Wang +10 more
wiley +1 more source
Ciclopirox Olamine Inhibits the NLRP3 Inflammasome to Alleviate Inflammatory Diseases
Advanced Science, EarlyView.There is no drug targeting the NLRP3 inflammasome that has been approved for use in clinical settings. Ciclopirox olamine (CPX), an antifungal agent approved by the US Food and Drug Administration (FDA), is identified as a specific and potent NLRP3 inflammasome inhibitor. CPX targets the NACHT domain of NLRP3 at Y381 to impair NLRP3 oligomerization and
Xinyu Xia +7 more
wiley +1 more source
Identifying Themes in the Knowledge and Attitudes of UK Healthcare Professionals Towards Transgender and Nonbinary Patients: An Evidence Review. [PDF]
Clin TeachMartin A, Preston L.
europepmc +1 more source
Backbone‐Length‐Optimized Inhibitors Deliver Long‐Retention Selectivity in Area‐Selective ALD of VO2
Advanced Science, EarlyView.Area‐selective VO2 ALD is found to depend critically on inhibitor backbone length, which governs physisorption, chemisorption stability, and packing efficiency in a coupled manner. An intermediate backbone‐length achieves the best long‐retention selectivity, establishing a chemically and geometrically grounded design principle for small‐molecule ...
Hae Lin Yang +9 more
wiley +1 more source
The role of gender, work family conflict, and gender role attitudes in daily parental wellbeing. [PDF]
Sci RepAltweck L, Schmidt S, Tomczyk S.
europepmc +1 more source
Gender Equality, Parenthood Attitudes, and First Births in Sweden
We analyse Swedish survey data on attitudes about parenthood among young adults aged 22-30 in 1999, and examine who became parents over the next four years.
Frances Goldscheider, Eva Bernhardt
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