Results 61 to 70 of about 518,472 (340)

IDENTIFICATION OF THE CSTATE OF THE ART AND ATTRACTIVENESSOF TRANSPORT BIOFUELS SECTORS IN POLAND [PDF]

open access: yesAnnals of the Polish Association of Agricultural and Agribusiness Economists, 2017
The current state of transport biofuels sectors in Poland was analysed - as well as the results of the research of theirattractiveness in the years 2007-2016 was showed.
Adam Kupczyk   +3 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

A Demonstration of the Collaborative Replication and Education Project: Replication Attempts of the Red-Romance Effect

open access: yesCollabra: Psychology, 2019
The present article reports the results of a meta-analysis of nine student replication projects of Elliot et al.’s (2010) findings from Experiment 3, that women were more attracted to photographs of men with red borders (total 'n' = 640).
Jordan R. Wagge   +8 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Methodology Of Assessing Investment Attractiveness Of Ukrainian Gas Producers [PDF]

open access: yes, 2018
The development of a methodology for assessing investment attractiveness of businesses of Ukrainian gas production industry that is presented in the form of a generalized algorithm reflects the conceptual model of research.
Pysar, N. (Nadiia)
core  

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

How target and perceiver gender affect impressions of HIV risk

open access: yesFrontiers in Public Health, 2015
Background: People do not use condoms consistently but instead rely on intuition to identify sexual partners high at risk for HIV infection. The present study examined gender differences of intuitive impressions about HIV risk.
Alexander eBarth   +4 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

Visual attractiveness is leaky: The asymmetrical relationship between face and hair

open access: yesFrontiers in Psychology, 2015
Predicting personality is crucial when communicating with people. It has been revealed that the perceived attractiveness or beauty of the face is a cue.
Chihiro eSaegusa   +4 more
doaj   +1 more source

Home - About - Disclaimer - Privacy