Results 61 to 70 of about 449,569 (262)
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
MoleculesThe integration of essential oils (EOs) with biological control agents offers a promising alternative to synthetic pesticides, though compatibility remains unclear.
Prangthip Parichanon +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Physical Disability Affects Women’s but Not Men’s Perception of Opposite-Sex Attractiveness
Frontiers in Psychology, 2021 Physical appearance influences our perceptions, judgments, and decision making about others. While the current literature with regard to the perceptions and judgments of nondisabled people’s attractiveness is robust, the research investigating the ...
Farid Pazhoohi +2 more
doaj +1 more source
An Universal Image Attractiveness Ranking Framework
, 2019 We propose a new framework to rank image attractiveness using a novel pairwise deep network trained with a large set of side-by-side multi-labeled image pairs from a web image index. The judges only provide relative ranking between two images without the
Bolin, Mark +5 more
core +1 more source
Molecular Attraction, VI. [PDF]
The Journal of Physical Chemistry, 1907 n ...
openaire +6 more sources
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
The Neural Correlates of Facial Attractiveness in Resume Screening: Evidence from ERPs
Behavioral SciencesFacial attractiveness plays a significant role in job search evaluations, with recruiters often rating candidates with higher levels of attractiveness more favorably.
Bin Ling, Yuting Xia, Yihan Wang
doaj +1 more source