Results 121 to 130 of about 3,221,975 (292)

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

open access: yesFEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen   +5 more
wiley   +1 more source

Attractor – a new turning point in drug discovery

open access: yesDrug Design, Development and Therapy, 2019
Xucan Hou, Meng Li, Congmin Jia, Xianbao Zhang, Yun WangDepartment of Traditional Chinese Medicine Information Fusion and Utilization, Beijing University of Chinese Medicine, Beijing, People’s Republic of ChinaCorrespondence: Yun WangDepartment of ...
Hou X, Li M, Jia C, Zhang X, Wang Y
doaj  

Simplicial Models for the Global Dynamics of Attractors

open access: yesJournal of Differential Equations, 2000
The author considers a flow \(\phi\) on a compact metric space \(\mathcal{A}\) which has a Morse decomposition \(\{S_p\}_{p\in P}\) indexed by the partially ordered set \((P,
openaire   +1 more source

Recurrent neural networks from learning attractor dynamics

open access: yes, 2003
Many forms of recurrent neural networks can be understood in terms of dynamic systems theory of difference equations or differential equations. Learning in such systems corresponds to adjusting some internal parameters to obtain a desired time evolution ...
Schaal, S., Peters, J.
core  

Flickering state transition before a critical transition in attractor dynamics.

open access: yes, 2015
(a) and (b) represent critical transitions without and with noise in the attractor dynamics, respectively. The x-axis represents the effector sequence, and the y-axis denotes the state of the system.
Daewon Lee (803680)   +2 more
core   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

open access: yesFEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao   +10 more
wiley   +1 more source

Determinants of undergraduate bioscience engagement: Validating attendance barriers and classroom spatial behaviour across institutions

open access: yesFEBS Open Bio, EarlyView.
Student engagement extends beyond simple attendance. Across 891 bioscience students from three universities, attendance behaviour was associated mainly with structural influences, whereas classroom spatial behaviour reflected affective and sensory factors.
Nigel Page   +4 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

open access: yesAging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

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