Results 101 to 110 of about 361,806 (283)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Tobacco smoking-attributable mortality in Kenya, 2012–2021

Tobacco Induced Diseases
Introduction Tobacco smoking poses a significant risk for various diseases, including cardiovascular diseases, chronic respiratory diseases, and cancers.
Lazarus Odeny, Gladwell Gathecha, Valerian Mwenda, Anne Kendagor, Samuel Cheburet, Beatrice Mugi, Caroline Mithi, Florence Jaguga, Kennedy Okinda, Rachel K. Devotsu, Shukri F. Mohamed, Jane Rahedi Ong’ang’o   +11 more
doaj   +1 more source

Suzaku X-Ray Observation of the Dwarf Nova Z Camelopardalis at the Onset of an Optical Outburst

, 2012
We present the result of a Suzaku X-ray spectroscopic observation of the dwarf nova Z Camelopardalis, which was conducted by chance at the onset of an optical outburst. We used the X-ray Imaging Spectrometer (a 38 ks exposure) and the Hard X-ray Detector
Ebisawa, Ken, Ishida, Manabu, Saitou, Kei, Tsujimoto, Masahiro   +3 more
core   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Trends in temperature-related age-specific and sex-specific mortality from cardiovascular diseases in Spain: a national time-series analysis

The Lancet Planetary Health, 2019
Summary: Background: Climate change driven by human activities has increased annual temperatures in Spain by around 1°C since 1980. However, little is known regarding the extent to which the association between temperature and mortality has changed ...
Hicham Achebak, MSc, Daniel Devolder, PhD, Joan Ballester, PhD   +2 more
doaj   +1 more source

How much of the Macroeconomic Variation in Eastern Europe is Attributable to External Shocks? [PDF]

We decompose by origin the sources of the variation in real aggregate output and aggregate price level in the Czech Republic, Hungary and Poland. We find that a sizable fraction of the variation is attributable to external shocks, especially so for ...
Bartosz Mackowiak
core  

Estimating the burden of disease attributable to smoking in South Africa in 2000 [PDF]

, 2007
Objectives. To quantify the burden of disease attributable to smoking in South Africa for 2000. Design. The absolute difference between observed lung cancer death rate and the level in non-smokers, adjusted for occupational and indoor exposure to lung ...
Groenewald, Pam, Vos, Theo, Norman, Rosana, Laubscher, Ria, Van Walbeek, Corne, Saloojee, Yussuf, Sitas, Freddy, Bradshaw, Debbie, The South African Comparative Risk Assessment Collaborating Group   +8 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Potential impact of controlling opium use prevalence on future cancer incidence in IranResearch in context

EClinicalMedicine
Summary: Background: The International Agency for Research on Cancer (IARC) recently classified opium consumption as carcinogenic to humans. This study aimed to estimate the potential reduction in incident cancers by 2035 in Iran, which accounts for 42%
Saeed Nemati, Amir Reza Dardashti, Elham Mohebbi, Farin Kamangar, Reza Malekzadeh, Kazem Zendehdel, Mahdi Sheikh   +6 more
doaj   +1 more source