Results 81 to 90 of about 361,806 (283)

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Estimation of Risk of Death Attributable to Acute Gastroenteritis Not Caused by Clostridioides difficile Infection Among Hospitalized Adults in England

Clinical Epidemiology, 2021
Maria Alexandridou, Tom Cattaert, Thomas Verstraeten P95 Pharmacovigilance and Epidemiology Services, Leuven, BelgiumCorrespondence: Thomas Verstraeten Email thomas.verstraeten@p-95.comIntroduction: The role of an infectious agent may be unclear as the ...
Alexandridou M, Cattaert T, Verstraeten T   +2 more
doaj  

Potential confounding in the association between short birth intervals and increased neonatal, infant, and child mortality [PDF]

Global Health Action, 2015
Background: Recent steep declines in child mortality have been attributed in part to increased use of contraceptives and the resulting change in fertility behaviour, including an increase in the time between births.
Jamie Perin, Neff Walker
doaj   +1 more source

Sepsis-related deaths in the at-risk population on the wards: attributable fraction of mortality in a large point-prevalence study [PDF]

, 2018
Objective Sepsis mortality is reported to be high worldwide, however recently the attributable fraction of mortality due to sepsis (AFsepsis) has been questioned.
Alex Gordon, Amit Kurani, Amy Noble, Angelica Sharma, Ben Sharif, Billie Atkins, Camilla Lee, Carys Durie, Carys Gilbert, Charlotte Maden, Claire Smith, Harriet Penney, Hazel Preston, Henry Atkinson, Jennifer Gee, Jessica Davis, Joy Inns, Jude Joseph-Gubral, Llewelyn Jones, Louise Pike, Lucy Allen, Maja Kopczynska, Matthew Bradley, Naomi Spencer, Navrhinaa Vadivale, Nicholas Doyle, Nik Syakirah Nik Azis, Rebecca Walford, Robyn Howcroft, Ross Edwards, Sian Cleaver, Tamas Szakmany, Welsh Digital Data Collection Platform Collaborators   +32 more
core   +3 more sources

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Rest-Frame Ultraviolet Spectra of z~3 Lyman Break Galaxies

, 2003
We present the results of a systematic study of the rest-frame UV spectroscopic properties of Lyman Break Galaxies (LBGs). The database of almost 1000 LBG spectra proves useful for constructing high S/N composite spectra.
Alice E. Shapley, Carigi L., Charles C. Steidel, Groenewegen M. A. T., Kunth D., Kunth D., Kurt L. Adelberger, Lequeux J., Maeder A., Maeder A., Max Pettini, Meynet G.   +11 more
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Estimating the Fraction of First-Year Hemodialysis Deaths Attributable to Potentially Modifiable Risk Factors: Results from the DOPPS

Clinical Epidemiology, 2020
Angelo Karaboyas, 1 Hal Morgenstern, 2 Yun Li, 3 Brian A Bieber, 1 Raymond Hakim, 4 Takeshi Hasegawa, 5 Michel Jadoul, 6 Elke Schaeffner, 7 Raymond Vanholder, 8 Ronald L Pisoni, 1 Friedrich K Port, 9 Bruce M Robinson 1 1Arbor Research Collaborative for ...
Karaboyas A, Morgenstern H, Li Y, Bieber BA, Hakim R, Hasegawa T, Jadoul M, Schaeffner E, Vanholder R, Pisoni RL, Port FK, Robinson BM   +11 more
doaj  

Cancers in Australia in 2010 attributable to infectious agents

Australian and New Zealand Journal of Public Health, 2015
Objectives: To estimate the proportion and numbers of cancers in Australia in 2010 attributable to infectious agents. Methods: The population attributable fraction (PAF) and number of cancers caused by hepatitis B and C viruses (HBV, HCV), Helicobacter ...
Annika Antonsson, Louise F. Wilson, Bradley J. Kendall, Christopher J. Bain, David C. Whiteman, Rachel E. Neale   +5 more
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source