Results 11 to 20 of about 1,882,955 (187)

Linguistic Study on the Sandipa Manuscript. Syntax (4.). Sentence Syntax (1.) [PDF]

Philologia, 2022
The article focuses on the description of syntactic processes that occur at the level of sentence parts. The characteristic features of the Subject, Predicate and Attribute from the text of the popular novel Sandipa are examined, a manuscript copy dated ...
Galaction VEREBCEANU
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Identification of critical chemical modifications and paratope mapping by size exclusion chromatography of stressed antibody-target complexes

mAbs, 2021
Therapeutic proteins including antibodies and Fc-fusion proteins undergo a large number of chemical modifications during cell culture, purification, storage and in human circulation.
Pavel V. Bondarenko, Andrew C. Nichols, Gang Xiao, Rachel Liuqing Shi, Pik Kay Chan, Thomas M Dillon, Fernando Garces, David J. Semin, Margaret S. Ricci   +8 more
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Use of the 2D ¹H-¹³C HSQC NMR Methyl Region to Evaluate the Higher Order Structural Integrity of Biopharmaceuticals

Molecules, 2021
The higher-order structure (HOS) of protein therapeutics is directly related to the function and represents a critical quality attribute. Currently, the HOS of protein therapeutics is characterized by methods with low to medium structural resolution ...
Tsang-Lin Hwang, Dipanwita Batabyal, Nicholas Knutson, Mats Wikström   +3 more
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Identification of critical chemical modifications by size exclusion chromatography of stressed antibody-target complexes with competitive binding

mAbs, 2021
Chemical modifications (attributes) in the binding regions of stressed therapeutic proteins may affect binding to target and efficacy of therapeutic proteins.
Rachel Liuqing Shi, Gang Xiao, Thomas M. Dillon, Arnold McAuley, Margaret S. Ricci, Pavel V. Bondarenko   +5 more
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Kinetic analysis of antibody binding to integral membrane proteins stabilized in SMALPs

BBA Advances, 2021
The fundamental importance of membrane protein (MP) targets in central biological and cellular events has driven a marked increase in the use of membrane mimetics for exploring these proteins as therapeutic targets.
Pooja Sharma, Matthew Plant, Sheung Kwan Lam, Qing Chen   +3 more
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Immune Complex Formation Is Associated With Loss of Tolerance and an Antibody Response to Both Drug and Target

Frontiers in Immunology, 2021
AMG 966 is a bi-specific, heteroimmunoglobulin molecule that binds both tumor necrosis factor alpha (TNFα) and TNF-like ligand 1A (TL1A). In a first-in-human clinical study in healthy volunteers, AMG 966 elicited anti-drug antibodies (ADA) in 53 of 54 ...
Mark A. Kroenke, Troy E. Barger, Jenny Hu, Mieke Jill Miller, Kevin Kalenian, Lidong He, Hailing Hsu, Yessenia Bartley, Vincent Fung-Sing Chow, Marcia Cristina Teixeira dos Santos, Barbara A. Sullivan, Laurence E. Cheng, Jane R. Parnes, Rupa Padaki, Scott Kuhns, Daniel T. Mytych   +15 more
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Fc glycan sialylation of biotherapeutic monoclonal antibodies has limited impact on antibody‐dependent cellular cytotoxicity

FEBS Open Bio, 2021
It has been well documented that the terminal sugars of Fc glycans can play a critical role in the safety and efficacy of therapeutic mAbs. However, many of the effects of highly heterogeneous Fc glycan structures have yet to be fully characterized ...
Elaine Branstetter, Robert J. Duff, Scott Kuhns, Rupa Padaki   +3 more
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Characterization of therapeutic proteins by cation exchange chromatography-mass spectrometry and top-down analysis

mAbs, 2020
Recently, cation exchange chromatography (CEX) using aqueous volatile buffers was directly coupled with mass spectrometry (MS) and applied for intact analysis of therapeutic proteins and antibodies.
Rachel Liuqing Shi, Gang Xiao, Thomas M. Dillon, Margaret S. Ricci, Pavel V. Bondarenko   +4 more
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CMC development of [14C]-labeled sotorasib for the conduct of microtracer human ADME study

AAPS Open, 2023
Human absorption, distribution, metabolism, and excretion (hADME) studies of new drugs are required for global regulatory filings. Recent advances in high sensitivity analytical technologies have enabled microtracer hADME studies wherein very low ...
Sonika Sharma, Prashant Agarwal, Andrew T. Parsons, James E. Huckle, Tiffany L. Correll   +4 more
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SEMANTIC AND SYNTACTIC FEATURES OF PREPOSITIONAL CASE FORMS OF THE LEXEME “STATE” IN THE RUSSIAN LANGUAGE (BASED ON LEO TOLSTOY’S PROSE)

Sovremennye Issledovaniâ Socialʹnyh Problem, 2022
The close attention of linguists to the anthropocentric approach in linguistics has been observed in recent decades. Constructions with the meaning of the subject state are the subject of research within the framework of this approach.
Svetlana A. Kabanova
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