Results 61 to 70 of about 22,243,278 (189)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Climate change detection and attribution: Beyond mean temperature signals [PDF]

, 2006
A significant influence of anthropogenic forcing has been detected in global- and continental-scale surface temperature, temperature of the free atmosphere, and global ocean heat uptake.
Xuebin Zhang, Hegerl, Gabriele C., Allen, M., Gillett, Nathan P., Bindoff, N. L., David Karoly, Nathaniel L. Bindoff, Hegerl, G. C., Karoly, D., Karoly, David J., Zwiers, Francis W., Gabriele C. Hegerl, Francis Zwiers, Karl, T. R., Bindoff, Nathaniel L., Karl, Thomas R., Zwiers, F., Zhang, X. B., Nathan Gillett, Thomas R. Karl, Myles Allen, Allen, Myles R., Gillett, N., Zhang, Xuebin   +23 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Identifying idiolect in forensic authorship attribution: an n-gram textbite approach [PDF]

, 2014
Forensic authorship attribution is concerned with identifying authors of disputed or anonymous documents, which are potentially evidential in legal cases, through the analysis of linguistic clues left behind by writers.
Wright, D, Johnson, A, Johnson, AJ
core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Attribution analysis of the persistent and extreme drought in southwest China during 2022–2023

Environmental Research Letters
Southwest China experienced a severe drought during winter 2022–spring 2023. This drought mainly struck Yunnan Province and surrounding regions (21°–30° N, 97°–106° E), with precipitation deficit lasting for about 8 months from Oct 2022 to May 2023.
Tianjiao Ma, Wen Chen, Qingyu Cai, Zizen Dong, Lin Wang, Peng Hu, Lu Gao, Chaim I Garfinkel   +7 more
doaj   +1 more source

Analysis of epidemiological characteristics of foodborne disease events in Nanping City from 1998 to 2017

Zhongguo shipin weisheng zazhi, 2020
Objective The epidemiological characteristics and patterns of foodborne disease events in Nanping City were analyzed to provide a basis for formulating prevention and control strategies of foodborne disease.
Xinyou HUANG, Zhiping ZHANG, Zhenjiang LIU, Chunlei WU, Yingting CHENG, Hua CHEN, Mingjian YANG   +6 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source