Results 51 to 60 of about 521,914 (305)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Who is responsible for self-AI or others-AI collaboration? The effect of power and task outcome in responsibility attribution

Acta Psychologica
Humans increasingly collaborate with Artificial Intelligence (AI), raising critical questions about responsibility attribution for task outcomes: when a collaboration succeeds or fails should the human be held responsible or AI?
Wenxing Hu, Zonghuo Yu, Jing Xu, Wenzheng Lin, Junhua Dang, Eric van Dijk   +5 more
doaj   +1 more source

Contribution of International Responsibility Among States in Connection with the Act of Another State or Organization [PDF]

دولت‌پژوهی, 2018
Nowadays, many wrongful acts have been committed in the international community that multiple states play role in its commission. In spite of recognizing Independent Responsibility as the cornerstone basis for allocating international law of ...
Mahdy Haddady, Mohamad Setayeshpur
doaj   +1 more source

Expectations and attribution of responsibility

Revus, 2015
Under the hypothesis that every attribution of responsibility rests on the fact that an expectation has been breached, the author proposes to understand expectations as standards adopted by a community to evaluate specific events and allow the members of the community to search for an explanation of the events which breach expectations.
openaire   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Research on Ethical Issues in the Design of Intelligent Assistive Devices: Privacy, Security, and Responsibility [PDF]

SHS Web of Conferences
With the widespread application of intelligent assistive devices, ethical issues in their design are becoming increasingly prominent. This paper explores ethical issues in the design of intelligent assistive devices from three aspects: privacy protection,
Yang Haokun
doaj   +1 more source

Reconstructing the effective control criterion in extraterritorial human rights breaches : direct attribution of wrongfulness, due diligence, and concurrent responsibility [PDF]

, 2014
The paper discusses the rather thorny question of extraterritoriality in human rights protection and the effective control criterion developed by the European Court of Human Rights with a view to delimit territorially the ambit of human right obligations.
Tzevelekos, Vassilis P.
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Language matters: an experimental study of language patterns' effects on traffic safety perceptions in Germany

Traffic Safety Research
Traffic crashes claim over 1.19 million lives globally each year, yet public support for proven safety measures remains limited. Research suggests that media language patterns may influence public perceptions of traffic violence and policy preferences ...
Dirk von Schneidemesser, Hugo Caviola
doaj   +1 more source

How Sustainability Ratings Might Deter "Greenwashing": A Closer Look at Ethical Corporate Communication [PDF]

Of the many ethical corporate marketing practices, many firms use corporate social responsibility (CSR) communication to enhance their corporate image.
Béatrice Parguel, Fabrice Larceneux, Florence Benoît-Moreau   +2 more
core   +3 more sources