Results 61 to 70 of about 521,914 (305)

Denying humanness to victims: How gang members justify violent behavior [PDF]

, 2014
The high prevalence of violent offending amongst gang-involved youth has been established in the literature. Yet the underlying psychological mechanisms that enable youth to engage in such acts of violence remain unclear.
Anderson E., Bandura A., Chan D., Coaley K., Elizabeth Pritchard, Emler N., Emma Alleyne, Giner-Sorolla R., Haslam N., Home Office, Home Office, Home Office, Isabel Fernandes, Klein M. W., Kline P., Milgram S., Miller J., Sivarajasingam V., Staub E., Tajfel H., Thornberry T. P., Vigil D. V., Young T.   +22 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Rebels, Negligent Support, and State Accountability: Holding States Accountable for the Human Rights Violations of Non-State Actors [PDF]

, 2013
This Note discusses a crucial problem in the law of state accountability for human rights abuses. Specifically, it analyzes the difficulty of attaching liability when a state negligently supports a group that it should reasonably expect to commit human
Cronogue, Graham
core   +1 more source

Morality and Psychopathic Criminals. Ethicocentrism, Mental Incapacity, Free Will, and the Fear of Decriminalization [PDF]

, 2012
Present-day legal judgments of psychopathic criminals strongly avoid the exploitation of “moral” considerations. Currently, the attribution of responsibility to criminals often takes advantage of the cognitive concept of mental incapacity so that, in ...
Lorenzo Magnani
core   +3 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Attribution of pollution generation to local private and public demands in a small open economy: results from a SAM-based neo-classical linear attribution system for Scotland [PDF]

, 2004
For the construction of environmental accounts, Input Output (IO) systems have a number of clear advantages. First IO is an internally consistency, rigorous accounting framework. Second, the characteristics of IO systems are well known. Third, IO systems
McGregor, P.G., McLellan, D., Swales, J.K., Turner, K.   +3 more
core  

Character, Choice and Criminal Responsibility [PDF]

, 1998
Le présent article examine la responsabilité criminelle et le rôle des excuses selon deux points de vue théoriques différents: la théorie fondée sur le caractère de l'accusé (« the character theory ») et la théorie de la responsabilité fondée sur le ...
Mousourakis, George
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Responsibility: identifying purpose and finding meaning [PDF]

, 2015
This is the author accepted manuscript. The final version is available from Taylor & Francis (Routledge) via the DOI in this record.The social and legal practices of blaming, praising, punishing and rewarding are inextricably linked with the process of ...
Price, L
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source