Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity
FEBS Open Bio, EarlyView.Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz +9 more
wiley +1 more source
ATTRIBUTION AND MODALITY OF RESPONSIBILITY IN THE INFORMATION SOCIETY
Вісник НЮУ імені Ярослава Мудрого: Серія: Філософія, філософія права, політологія, соціологія, 2018 Problem setting. The current stage of development of society is characterized by intensive development and dissemination of information technologies, high level of technical power, global social and cultural transformations.
Світлана Борисівна Жданенко
doaj +1 more source
Technological Threat Attribution, Trust and Confidence, and the Contestability of National Security Policy [PDF]
, 2018 The world has been asked to believe that China is a source of cyberthreat and that Russia is meddling in U.S. elections. Western populations are being asked to trust the words of intelligence agencies and world leaders that these unspecified ...
Hoverd, W
core
Public perceptions of self-harm: a test of an attribution model of public discrimination [PDF]
, 2017 This cross-sectional, questionnaire-based study applied Corrigan, Markowitz, Watson, Rowan, and Kubiak’s (2003) attribution model of public discrimination toward individuals with mental ill-health to explore public perceptions of self-harm—an ...
Nielsen, Emma, Townsend, Ellen
core +2 more sources
ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells
FEBS Open Bio, EarlyView.Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori +8 more
wiley +1 more source
An Asymmetrical Approach to Kant's Theory of Freedom [PDF]
Asymmetry theories about free will and moral responsibility are a recent development in the long history of the free will debate. To my knowledge, Kant commentators have not yet explored the possibility of an asymmetrical reconstruction of Kant's theory
Vilhauer, Benjamin
core
SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1
FEBS Open Bio, EarlyView.Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl +13 more
wiley +1 more source
FEBS Open Bio, EarlyView.Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava +3 more
wiley +1 more source
From wrongdoing to imprisonment: Test of a causal–moral model
IIMB Management Review, 2012 The authors tested a causal–moral model of punishment in which (a) causal attribution and moral responsibility are distinct precursors of punishment, and (b) dispositional attribution leads to blame which, in turn, determines imprisonment.
Ramadhar Singh +9 more
doaj +1 more source
Identifying Hate Speech and Attribution of Responsibility: An Analysis of Simulated WhatsApp Conversations during the Pandemic. [PDF]
Healthcare (Basel), 2023 Palazón-Fernández JL +5 more
europepmc +1 more source