Results 71 to 80 of about 90,507 (251)

KCNJ4 variants disrupt inward‐rectifier potassium channel function and cause refractory epilepsy

Epilepsia, EarlyView.
Abstract Objective Epilepsy is a common neurological disorder with a strong genetic basis, most frequently arising from ion channel dysfunction. Although multiple inwardly rectifying potassium (Kir) channels have been implicated in epileptogenesis, the contribution of KCNJ4, which encodes the Kir2.3 channel, has not previously been established in human
Hu Pan, Deng Liu, Wuhen Xu, Yang Li, Juanli Hu, Oppermann Henry, Alexander Fuchs, Rami Abou Jamra, Zhen Liu, Mei He, Yuanlu Chen, Shengnan Wu, Xiaohuan Dong, Yiqiao Chen, Pengchao Wang, Weiyue Gu, Han Jing, Yabing Tang, Ya‐Jie Wang, Xiao Mao, Neng Xiao   +20 more
wiley   +1 more source

The TRIP database showed most Acute Respiratory Infections questions were already addressed by Cochrane reviews [PDF]

, 2019
OBJECTIVE: Cochrane systematic reviews require more methodological support from Cochrane Review Groups (CRGs) than is customary in journals, CRGs must prioritise reviews to conserve resources.
Brassey, Jon, Carter, Matt, Clark, Justin, Del Mar, Chris, Scott, Anna Mae   +4 more
core   +1 more source

Stiripentol: Unpublished results from the first phase 2 clinical trial in Lennox–Gastaut syndrome conducted in the early 1990s

Epilepsia, EarlyView.
Abstract Objective This study was undertaken to present the results of an exploratory phase 2 trial of stiripentol in Lennox–Gastaut syndrome (LGS). Methods This exploratory single‐blind, single‐arm, nonrandomized sequential‐period phase 2 study was conducted at four centers in France between January 1989 and August 1993.
Stéphane Auvin, Benjamin Serraz, Jérémie Lespinasse, Laurent Chancharme   +3 more
wiley   +1 more source

Acute Jaundice in a Six-year-old: An Unusual Presentation of Atypical Kawasaki Disease [PDF]

, 2020
Kawasaki disease (KD) is a rare vasculitis of childhood that is critical to recognize and treat due to associated morbidity and mortality. A six-year-old male presented to our emergency department (ED) afebrile but with reported recent fevers.
Bylund, LCDR William, Morrison Ponce, LCDR Daphne, Zarow, Gregory J.   +2 more
core  

Extrahepatic complications of liver transplantation. [PDF]

, 1985
The massive surgical assault associated with hepatic transplantation makes a high frequency of complications almost inevitable. In this review of 225 patient records, selected at random from cases of liver transplantation in Pittsburgh over a 2 1/2 year ...
Shaw, BW, Starzl, TE, Wood, RP
core   +1 more source

Faecal Microbiota Transplantation in Anorexia Nervosa: A Systematic Review of Methodologies, Outcomes, and Challenges With Recommendations for Future Studies

European Eating Disorders Review, EarlyView.
ABSTRACT Objective Anorexia nervosa (AN) is a severe psychiatric disorder displaying an altered gut microbiome. Faecal microbiome transplantation (FMT) has emerged as a powerful research tool and potential treatment option in AN due to the microbiome‐gut‐brain axis. Current studies are limited and reveal variable FMT protocols.
Anna C. Thelen, Nele M. Korten, Larissa Blischke, Clara Voelz, Cordian Beyer, Jochen Seitz, Stefanie Trinh   +6 more
wiley   +1 more source

Multiple pneumatoceles and diffuse ground‐glass opacities in a 20‐month‐old boy with COVID‐19 pneumonia

Respirology Case Reports, 2021
Key message Chest computed tomography characteristics of coronavirus disease 2019 (COVID‐19) in paediatric patients have been reported to be atypical and different compared to adults.
Cihan Özgür, Caner Doğan
doaj   +1 more source

Standardized Management Pathway to Prevent Acute Rejection After Liver Transplantation Following ICI Therapy for Downstaging HCC

Health Care Science, EarlyView.
Findings indicate that within a standardized clinical pathway integrating structured immunosuppression, therapeutic drug monitoring, and early complication surveillance, liver transplantation after ICI exposure can be performed safely without increased rejection risk.
Ning Wang, Zebin Zhu, Hao Zheng, Can Qi, Xiaodong Yuan, Xuefeng Li, Zhijun Xu, Jiwei Qin, Wei Wu, Jizhou Wang, Ruipeng Song, Zhiyong Guo, Lianxin Liu, Shu‐Geng Zhang, Björn Nashan   +14 more
wiley   +1 more source

A case-control study on Chlamydia psittaci pneumonia and legionella pneumonia

Frontiers in Medicine
PurposeAtypical pathogens (Chlamydia psittaci and Legionella) are often detected by metagenomic next-generation sequencing (mNGS). However, the two atypical pneumonias are difficult to distinguish. The aim of this study was to retrospectively analyze the
Ying Gao, Yuan-jie Lin, Wen-long Zhang, Jian-ming Ni, Shu-guang Han, Liang Bao   +5 more
doaj   +1 more source

EVALUATION OF THE PREVALENCE OF INFECTION BY ATYPICAL GERMS IN PATIENTS WITH COMMUNITY ACQUIRED PNEUMONIA IN A PERUVIAN REFERENCE HOSPITAL

Revista de la Facultad de Medicina Humana, 2019
Objective: To determine the prevalence of infection due to atypical microorganisms in cases of communityacquired pneumonia in adult inmunocompetent patients seeking attention in the Hospital Nacional Hipolito Unanue.
Alonso Soto
doaj   +1 more source