Results 241 to 250 of about 748,707 (290)

Ahcy Acts as an Effector of Hnf4a‐Driven Super‐Enhancer Activation to Alleviate MASLD During Intermittent Fasting

Advanced Science, EarlyView.
Our study identifies an Hnf4a‐driven super‐enhancer of hepatic Ahcy that mediates the protective effects of intermittent fasting against MASLD. Disruption of the Ahcy super‐enhancer reduces Ahcy expression and exacerbates lipid accumulation. This pathway prevents aberrant promoter hypermethylation by maintaining the SAM/SAH balance, as exemplified by ...
Huafeng Chen, Shilin Zhang, Xiaojie Deng, Wenqiang Xie, Fen Xu, Jie Shen, Hua Liang   +6 more
wiley   +1 more source

Prioritizing next-day readiness decline in elite female soccer using readiness, workload, and wellness data: A temporally validated and calibrated monitoring framework. [PDF]

PLoS One
Long H, Li L, Zhang L.
europepmc   +1 more source

Intratumoral Hypoxia Triggers Mitochondrial BHLHE40 ROS Sensing Pathway to Promote Radioresistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Hypoxia triggers a dual mechanism for BHLHE40 upregulation: reactive oxygen species (ROS)‐dependent post‐translational modification and hypoxia‐inducible factor (HIF)‐dependent transcriptional activation. Under hypoxic conditions, mitochondrial BHLHE40 accumulates and senses ROS via cysteine thiol oxidation and disulfide‐linked homodimer formation ...
Jia Liu, Ziliang Nie, Xi Chen, Guangyu Ji, Yajing Zhang, Zhiqun Zhao, Yuhong Zhang, Xinlong Du, Zhenzhen Zhou, Jiayi Li, Yaozong Yang, Fengqi Sun, Zhibo Yan, Haiquan Lu   +13 more
wiley   +1 more source

Bending‐Stable Pressure Sensor Based on Natural Wood Nanofibers for Ultra‐Low Detection Limit

Advanced Science, EarlyView.
A wood nanofiber‐based flexible pressure sensor with intrinsic bending‐stable performance is developed through a porous electrospun architecture and interdigital electrode design. The device exhibits an ultra‐low detection limit and stable operation under deformation for physiological monitoring and spatial sensing, providing a sustainable strategy for
Xu Zeng, Zhengnan Sun, Yilin Wang, Yao Tan, Ranran Xu, Beomjoon Kim, Juergen Brugger, Xiaosheng Zhang   +7 more
wiley   +1 more source

Diagnostic performance of artificial intelligence models trained on scattered single-cell images is not preserved for hyperchromatic crowded cell groups in cervical cytology. [PDF]

Cancer Cytopathol
Tanaka S, Yamamoto Y, Yokota K, Yamamoto T, Teramoto N.   +4 more
europepmc   +1 more source

Assessment of emphysema with simulated low-dose dark-field radiography. [PDF]

Eur Radiol Exp
Bast H, Schick RC, Koehler T, Gassert FT, Marka AW, Sauter AP, Renger B, Zimmermann G, Makowski MR, Pfeiffer F, Pfeiffer D.   +10 more
europepmc   +1 more source

Bursting Parameters Alter Excitatory Postsynaptic Currents in Nucleus Tractus Solitarius Neurons: Implications for Clinical Vagus Nerve Stimulation. [PDF]

J Neurochem
Owens MM, Radovic A, Beaumont E.
europepmc   +1 more source