Results 121 to 130 of about 2,755,800 (242)

Orthogonal Light‐ and Enzyme‐Triggered and‐Gate Prodrugs for Senolytic Therapy

Advanced Science, EarlyView.
An orthogonal AND‐gate prodrug platform combines 390 nm near‐UV photocleavage with SA‐β‐gal activation to control payload release in senescent cells. Its modular architecture enables 4‐MU fluorescence, doxorubicin‐mediated cytotoxicity, and ARV‐771‐driven BRD4 degradation, supporting stimulus‐controlled senolytic design in cellular and organoid models.
Mengyang Chang, Kaixue Zhang, Junwei Wang, Fangchao Bi, Zhuoxin Dai, Miao Yang, Ming Liu, Huanzhi Peng, Franklin Zhang, Yuan Guo, Jigang Dai, Quanxing Liu, Wei Wang   +12 more
wiley   +1 more source

Biennial report : Legislative Post Audit Committee and the Legislative Division of Post Audit, fiscal years 1981 and 1982.

, 1982
"A Report to the Kansas Legislature by the Legislative Post Audit Committee, state of Kansas."; "September 3, 1982.
Kansas. Legislative Post Audit Committee.
core   +1 more source

LLM‐Assisted Design of Ultralow‐κ$\kappa$ Chalcogenides

Advanced Science, EarlyView.
An AI assisted, physics guided workflow accelerates the discovery of ultralow thermal conductivity materials by combining Bayesian optimization, evidence conditioned LLM reasoning, and automated physics‐based validation. The framework uncovers dynamically stable Ag based chalcogenides with ultralow thermal conductivity and promising thermoelectric ...
Yujie Liu, Congran Jia, Yuzhou Hao, Xuejie Li, Yang Wang, Artem Oganov, Jun Sun, Xiangdong Ding, Turab Lookman, Zhibin Gao   +9 more
wiley   +1 more source

Mechanism‐Informed Language Modeling and Oxygenated 3D Screening Identify Berberine–Enzalutamide Synergy in Prostate Cancer Models

Advanced Science, EarlyView.
By integrating knowledge‐augmented artificial intelligence with an oxygen‐supplemented 3D screening platform, a synergistic interaction between berberine and enzalutamide is identified. The framework integrates compound mechanisms of action with disease‐relevant signaling context to prioritize candidate combinations and generate testable pathway‐based ...
Chih‐Hui Lo, Katie Shi, Lina Kafadarian, Alexandra Bermudez, Johnny Diaz, Liam Edwards, Yunqi Hong, Ziyi Chen, Hyeonji Hwang, Weihong Yan, Alan Levinson, Robert Damoiseaux, Cho‐Jui Hsieh, Tanya Stoyanova, Andrew S. Goldstein, Neil Y.C. Lin   +15 more
wiley   +1 more source

CausalCellInfer: Prioritizing Cell‐Type‐Specific Disease Associations From Genetically Predicted Transcriptomes in Biobank Cohorts

Advanced Science, EarlyView.
Bulk and genotype‐imputed transcriptomes obscure the cellular drivers of complex disease. CausalCellInfer resolves them by integrating invariant marker selection, deep learning deconvolution, and regularized matrix completion. Applied to ∼500 000 UK Biobank participants across 29 traits, it uncovers hallmark cell‐type proportion shifts, including ...
Liangying Yin, Yujia Shi, Ruoyu Zhang, Yong Xiang, Jinghong Qiu, Pak‐Chung Sham, Hon‐Cheong So   +6 more
wiley   +1 more source

Climate Change is Rewriting the Hydroclimatic Operating Envelope of Mines

Advanced Science, EarlyView.
Climate change is shown to shift the hydroclimatic operating envelope of mines: 16.2% of represented mine locations have already changed Köppen subtype, rising to 42.5% by late century under SSP5‐8.5. Divergent water trajectories are filtered through geology, infrastructure and lifecycle stage, indicating that adaptation requires monitored, scenario ...
Haoxuan Yu, Izni Zahidi, Chow Ming Fai, Jilong Pan   +3 more
wiley   +1 more source

A Dual‐Delivery System Designed to Overcome EV‐Mediated Ferroptosis Resistance for Efficient Solid Tumor Therapy

Advanced Science, EarlyView.
(A) Establishment and characterization of the osteosarcoma‐targeted dual‐delivery nanoplatform mBAP1/siENO1@LNP‐OTP for simultaneous regulation of BAP1 and ENO1 in tumor cells. (B) After intravenous administration, mBAP1/siENO1@LNP‐OTP preferentially accumulates at tumor sites through OTP‐mediated targeting.
Yechao Shen, Zhenguo Cao, Zenan Wang, Liang Chen, Jiahao Zhang, Linjie Zeng, Boren Tan, Hengyuan Li, Jiashan Lai, Jiangchu Lei, Fanglu Chen, Peng Lin, Zhenxuan Shao, Zhan Wang   +13 more
wiley   +1 more source

Financial and compliance audit report: State of Kansas Fiscal Year 2010

, 2011
application/pdf; "February 2011."; "A Report to the Legislative Post Audit Committee" ...
Allen, Gibbs & Houlik.
core   +1 more source

From Spectral Maps to Biomedical Evidence: A Minimum Evidentiary Framework for Label‐Free Raman Imaging (Reply to Letter‐to‐the‐Editor)

Advanced Science, EarlyView.
Jiaxin Li, Xiaoyu Zhao, Jun Yu
wiley   +1 more source

Serial H&E Pathology Reveals Progression‐Associated Nuclear Size Drift as a Longitudinal Digital Readout of Bladder Cancer Evolution

Advanced Science, EarlyView.
Routine serial H&E specimens from bladder cancer are converted into paired T0/T1 digital pathology readouts of tumor evolution. Progression is associated with longitudinal nuclear drift, with nuclear size‐related changes most evident in the independent confirmation cohort, alongside a broader spatial burden of increased nuclear area and biological ...
Xing Liu, Zhen‐Duo Shi, Gong‐Cheng Wang, Jian‐Ming Wang, Ying Liu, Yi Gong, Xuan Lin, Di Wu, Shi‐Chao Zhuo, Han Han, Yi‐Bing Shi, Fan‐Lai Meng, Yu Zhang, Zhi‐Gang Jia, Cong‐Hui Han   +14 more
wiley   +1 more source